{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T01:37:01Z","timestamp":1778290621550,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T00:00:00Z","timestamp":1377734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the rates of cancer\u2010specific mortality, other\u2010cause and bladder cancer mortality in patients with upper\u2010tract urothelial carcinoma undergoing radical nephroureterectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Relying on the Surveillance, Epidemiology, and End Results database, 9899 patients treated with radical nephroureterectomy were identified. A 20\u2010strata graphical aid was constructed using age (&lt;60, 60\u201369, 70\u201379, &gt;79\u2009years) and American Joint Committee on Cancer\/<jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content> stage (<jats:styled-content style=\"fixed-case\">pT<jats:sub>1<\/jats:sub>N<jats:sub>0<\/jats:sub><\/jats:styled-content><jats:sub>\/x<\/jats:sub>, <jats:styled-content style=\"fixed-case\">pT<jats:sub>2<\/jats:sub>N<jats:sub>0<\/jats:sub><\/jats:styled-content><jats:sub>\/x<\/jats:sub>, <jats:styled-content style=\"fixed-case\">pT<jats:sub>3<\/jats:sub>N<jats:sub>0<\/jats:sub><\/jats:styled-content><jats:sub>\/x<\/jats:sub>, <jats:styled-content style=\"fixed-case\">pT<jats:sub>4<\/jats:sub>N<jats:sub>0<\/jats:sub><\/jats:styled-content><jats:sub>\/x<\/jats:sub>, <jats:styled-content style=\"fixed-case\">pT<jats:sub>any<\/jats:sub>pN<jats:sub>1<\/jats:sub><\/jats:styled-content><jats:sub>\u20133<\/jats:sub>) as stratifying variables. The 5\u2010year cancer\u2010specific mortality, other\u2010cause and bladder cancer mortality rates were generated through competing\u2010risks <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>oisson regression methodologies. Multivariable competing\u2010risks regression models were used to test the effect of age and stage on three different end\u2010points: cancer\u2010specific mortality, other\u2010cause and bladder cancer mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 1797 (18.1%), 891 (9.1%) and 3090 (31.2%) patients died of cancer\u2010specific mortality, other\u2010cause and bladder cancer mortality, respectively. Following stratification according to age and stage, the proportion of patients who succumbed to cancer\u2010specific mortality (11.7\u201321.9%) and other\u2010cause mortality (8.9\u201330.4%) increased with age. In contrast, with increasing stage, the proportion of patients who died of cancer\u2010specific mortality increased (7.2\u201337.5%), whereas the proportion of other\u2010cause mortality remained stable (18.9\u201322.0%). The rate of bladder cancer mortality increased with advancing stage. At multivariable competing\u2010risk regression model, besides age and stage, women, type of surgery, grade and location were associated with higher cancer\u2010specific mortality. Furthermore, ureteral location, stage and grade were associated with bladder cancer mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The developed graphical aid for prediction of cancer\u2010specific mortality, other\u2010cause, and bladder cancer mortality according to age and stage in patients with upper\u2010tract urothelial carcinoma undergoing radical nephroureterectomy can be useful for physicians and patients during clinical counseling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12267","type":"journal-article","created":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T03:58:07Z","timestamp":1377835087000},"page":"249-256","source":"Crossref","is-referenced-by-count":20,"title":["Survival after nephroureterectomy for upper tract urothelial carcinoma: A population\u2010based competing\u2010risks analysis"],"prefix":"10.1111","volume":"21","author":[{"given":"Giorgio","family":"Gandaglia","sequence":"first","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit University of Montreal Health Centre  Montreal Quebec Canada"},{"name":"Department of Urology Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit University of Montreal Health Centre  Montreal Quebec Canada"},{"name":"Department of Urology Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quoc\u2010Dien","family":"Trinh","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit University of Montreal Health Centre  Montreal Quebec Canada"},{"name":"Department of Surgery Division of Urology, Brigham and Women's Hospital\/Dana\u2010Farber Cancer Institute Harvard Medical School  Boston Massachusetts 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