{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:22:18Z","timestamp":1784334138255,"version":"3.55.0"},"reference-count":86,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,30]],"date-time":"2013-09-30T00:00:00Z","timestamp":1380499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Small\u2010vessel disease of the brain affecting the deep white matter characteristically manifests with neurological syndromes, such as vascular dementia and vascular parkinsonism. There is, however, compelling evidence to suggest that white matter disease can cause overactive bladder and incontinence, and in some patients these might be the initial manifestation. As white matter disease increases significantly with age, and preferentially affects the prefrontal deep white matter, white matter disease becomes an anatomical substrate in the brain etiology of overactive bladder. Treatment entails the management of small\u2010vessel disease risk factors and anticholinergic drugs that do not easily penetrate the blood\u2013brain barrier, to improve bladder control. In short, when caring for elderly overactive\u2010bladder patients, we should look at both the brain and the bladder.<\/jats:p>","DOI":"10.1111\/iju.12288","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:50:39Z","timestamp":1381528239000},"page":"33-38","source":"Crossref","is-referenced-by-count":65,"title":["Is overactive bladder a brain disease? 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