{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:38:59Z","timestamp":1787243939505,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T00:00:00Z","timestamp":1384300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"\n Objective<\/jats:title>\n To investigate the efficacy of urine alkalization therapy using citrates in patients with hypersensitive bladder syndrome.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 76 patients with urinary frequency were assessed for their symptoms using a 2\u2010day voiding diary as well as the urine\n pH<\/jats:styled-content>\n at each voiding during the screening period. Their symptoms were also assessed by pain score,\n K<\/jats:styled-content>\n ing's health questionnaire, and\n O<\/jats:styled-content>\n '\n L<\/jats:styled-content>\n eary\u2013\n S<\/jats:styled-content>\n ant symptom and problem index scores. Finally, 50 patients were evaluated for changes in symptoms after oral treatment with citrates for 2\u20134\u2009weeks after the screening period.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n After the treatment, significant increases in the urine\n pH<\/jats:styled-content>\n (from 5.8\u2009\u00b1\u20090.4 to 6.3\u2009\u00b1\u20090.4; increment of 0.5\u2009\u00b1\u20090.4;\n P<\/jats:italic>\n \u2009<\u20090.01), and significant decreases in the number of micturitions per day (from 14.5\u2009\u00b1\u20096.5 to 13.5\u2009\u00b1\u20095.9;\n P<\/jats:italic>\n \u2009=\u20090.02) and the number of episodes of pain\/discomfort per day (from 7.8\u2009\u00b1\u20096.8 to 6.1\u2009\u00b1\u20097.1;\n P<\/jats:italic>\n \u2009=\u20090.02) were observed. In the\n K<\/jats:styled-content>\n ing's health questionnaire, the sleep\/energy domain score was significantly improved (from 60.0\u2009\u00b1\u200925.0 to 50.3\u2009\u00b1\u200929.6;\n P<\/jats:italic>\n \u2009<\u20090.01). In a subgroup analysis based on urine\n pH<\/jats:styled-content>\n (urine\n pH<\/jats:styled-content>\n <6.2 and \u22656.2), significant improvements in the voiding symptoms, the sleep\/energy domain score and the\n O<\/jats:styled-content>\n '\n L<\/jats:styled-content>\n eary\u2013\n S<\/jats:styled-content>\n ant problem index were observed in the group with urine\n pH<\/jats:styled-content>\n of \u22656.2. There were statistically significant differences between the subgroups in the volume per voiding, maximum volume per voiding and the problem index. In addition, the subgroup, in which patients had pain in the screening period, showed statistically significant improvements in the number of micturitions per day, episodes of pain\/discomfort per day, the sleep\/energy domain score and the problem index.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Urine alkalization therapy is likely to be effective in the treatment for hypersensitive bladder syndrome.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/iju.12324","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T23:01:39Z","timestamp":1384383699000},"page":"512-517","source":"Crossref","is-referenced-by-count":18,"title":["Urine alkalization improves the problems of pain and sleep in hypersensitive bladder syndrome"],"prefix":"10.1111","volume":"21","author":[{"given":"Tomohiro","family":"Ueda","sequence":"first","affiliation":[{"name":"Department of Urology Ueda Clinic Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Urology Kyoto City Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Tanoue","sequence":"additional","affiliation":[{"name":"Department of Urology Kyoto City Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Urology Kyoto City Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Society Wakayama Medical Center Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Urology Seirei Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2007.01907.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12143"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2009.02326.x"},{"key":"e_1_2_8_5_1","first-page":"9","article-title":"Diagnosis of interstitial cystitis\/painful bladder syndrome in patients with overactive bladder symptoms","volume":"9","author":"Macdiarmid SA","year":"2007","journal-title":"Rev. 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