{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:54:30Z","timestamp":1781704470401,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the relationship between hypoxia and metallothionein expression in bladder biopsies of interstitial cystitis\/painful bladder syndrome patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study group consisted of 41 patients with interstitial cystitis\/painful bladder syndrome, and the control group consisted of 12 volunteers without any interstitial cystitis\/painful bladder syndrome symptoms. All biopsy specimens were analyzed for both proteins of hypoxia\u2010inducible factor\u20101\u03b1 and metallothionein expression by immunoblotting, immunostaining and confocal laser scanning microscopy. Data were analyzed using the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ann\u2013<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>hitney <jats:italic><jats:styled-content style=\"fixed-case\">U<\/jats:styled-content><\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An increased expression of hypoxia\u2010inducible factor\u20101\u03b1 and metallothionein was noted in the study group compared with the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Both proteins of hypoxia\u2010inducible factor\u20101\u03b1 and metallothionein mainly distributed over bladder urothelium by immunohistochemical staining, and showed co\u2010localization under confocal microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High expression and co\u2010localization of metallothionein and hypoxia\u2010inducible factor\u20101 alpha in the bladder mucosa of patients with interstitial cystitis suggest that overexpression of metallothionein is associated with the bladder hypoxia related to this disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12402","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T02:19:56Z","timestamp":1396491596000},"page":"719-723","source":"Crossref","is-referenced-by-count":12,"title":["Metallothionein overexpression of bladder biopsies associated with tissue hypoxia in patients with interstitial cystitis\/painful bladder syndrome"],"prefix":"10.1111","volume":"21","author":[{"given":"Jane\u2010Dar","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Urology Department of Surgery Taichung Armed Forces General Hospital  Taichung Taiwan"},{"name":"Central Taiwan University of Science and Technology  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Huei","family":"Lee","sequence":"additional","affiliation":[{"name":"Central Taiwan University of Science and Technology  Taichung Taiwan"},{"name":"Department of Urology Feng\u2010Yuan Hospital Ministry of Health and Welfare  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.03.084"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.02.050"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000180417.11976.99"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36253-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.05.050"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68552-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2004.02.040"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0426"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08467.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000021135.87203.92"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)41529-1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.5.H2292"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2003.07.013"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307907200"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14036044"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.05.048"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.01.008"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1258\/phleb.2011.011051"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2012.03.010"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-11-11"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2007.01599.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020668923852"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01101"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.09.049"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-007-0174-7"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-07-0341"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63514-6"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/940121"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920310791233378"},{"key":"e_1_2_8_31_1","first-page":"1145","article-title":"Metallothionein is up\u2010regulated under hypoxia and promotes the survival of human prostate cancer cells","volume":"18","author":"Yamasaki M","year":"2007","journal-title":"Oncol. Rep."}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiju.12402","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.12402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:35:05Z","timestamp":1696232105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.12402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,2]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/iju.12402"],"URL":"https:\/\/doi.org\/10.1111\/iju.12402","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,2]]}}}