{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:55:41Z","timestamp":1790805341509,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T00:00:00Z","timestamp":1402358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy of resiniferatoxin in the treatment of patients with lifelong premature ejaculation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 41 outpatients (mean age 26.14\u2009\u00b1\u20094 years) with premature ejaculation completed the present study. They were randomly separated into the resiniferatoxin group and the placebo group. The resiniferatoxin group included 11 patients with redundant prepuce and 10 patients without redundant prepuce, whereas the placebo group contained 10 patients with redundant prepuce and 10 patients without. For the treatment, the glans were respectively soaked in 30\u2009mL of resiniferatoxin with a concentration of 100\u2009nmol\/L or 10% alcohol solution for 30\u2009min before sexual intercourse. Clinical efficacy was assessed by using the<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese Index of Sexual Function for Premature Ejaculation\u20105 and the intravaginal ejaculation latency time before or 4 weeks after the treatment. The side\u2010effects were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the resiniferatoxin group, the effective rate of patients with redundant prepuce was 63.6%, and both the intravaginal ejaculation latency time and<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese Index of Sexual Function for Premature Ejaculation\u20105 significantly increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). However, the effective rate of patients without redundant prepuce was 20%, and there were no significant changes of their intravaginal ejaculation latency time and<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese Index of Sexual Function for Premature Ejaculation\u20105 before and after the resiniferatoxin treatment (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). The total effective rate of patients treated with resiniferatoxin was 42.9%. In the placebo group, the effective rate of patients with or without redundant prepuce was 20% and 10%, respectively. The total effective rate of patients treated with placebo was 15%, and there were no significant changes of their intravaginal ejaculation latency time and<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese Index of Sexual Function for Premature Ejaculation\u20105 before and after the placebo treatment (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). The side\u2010effects included a slight burning sensation for the glans penis and dysuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These preliminary results show that resiniferatoxin might be suitable for treating patients with lifelong premature ejaculation and particularly those with redundant prepuce.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12471","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T09:46:56Z","timestamp":1402393616000},"page":"923-926","source":"Crossref","is-referenced-by-count":21,"title":["Resiniferatoxin for treatment of lifelong premature ejaculation: A preliminary study"],"prefix":"10.1111","volume":"21","author":[{"given":"Bentao","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Urology Peking University Shenzhen Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Peking University Shenzhen Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxing","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Urology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology Peking University Shenzhen Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology Peking University Shenzhen Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichen","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Urology Peking University Shenzhen Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas Medical School at Houston and University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901507"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65677-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63194-X"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0031-6997(24)01403-0","article-title":"Vanilloid (Capsaicin) receptors and mechanisms","volume":"51","author":"Szallasi A","year":"1999","journal-title":"Pharmacol. 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