{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:04:49Z","timestamp":1761807889899},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T00:00:00Z","timestamp":1403654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study the effect of carbazochrome sodium sulfonate, an agent that reduces capillary permeability, on refractory chronic prostatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with prostatitis refractory to at least 8 weeks of routine therapy and with urinalysis positive for microhematuria were considered for the present study. In addition to their prior therapy, the patients received carbazochrome at a dose of 30\u2009mg three times a day. The severity of pain (score 0\u201310), daytime and night\u2010time frequency, international prostate symptom score, global self\u2010assessment, urine occult blood positivity, and adverse events were assessed after 4 and 8 weeks of treatment, and compared with baseline findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 50 patients (mean age 68.6\u2009\u00b1\u20098.5 years) were evaluable. The pain score decreased significantly from 3.2\u2009\u00b1\u20092.1 at baseline to 1.7\u2009\u00b1\u20091.4 after 4 weeks of treatment and to 1.1\u2009\u00b1\u20091.8 after 8 weeks. Daytime and night\u2010time frequency, storage symptoms, post\u2010micturition symptoms, and urine occult blood positivity also significantly improved. More than 36% of the patients gave a global self\u2010assessment rating of \u201cimproved\u201d or \u201cbetter\u201d after both 4 and 8 weeks of treatment. Mild adverse events occurred in three patients; one had nausea and two developed drug rash.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Carbazochrome seems to effectively improve pain as well as storage and post\u2010micturition symptoms in patients with refractory chronic prostatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12533","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T08:37:32Z","timestamp":1403685452000},"page":"1162-1166","source":"Crossref","is-referenced-by-count":17,"title":["Effect of carbazochrome sodium sulfonate on refractory chronic prostatitis"],"prefix":"10.1111","volume":"21","author":[{"given":"Hitoshi","family":"Oh\u2010oka","sequence":"first","affiliation":[{"name":"Department of Urology National Hospital Organization Kobe Medical Center  Kobe Hyogo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Yamada","sequence":"additional","affiliation":[{"name":"Yamada Urological Clinic  Sagamihara Kanagawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromitsu","family":"Noto","sequence":"additional","affiliation":[{"name":"Akita Urologic Clinic  Akita Akita"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomokazu","family":"Umeyama","sequence":"additional","affiliation":[{"name":"Umeyama Clinic  Takasaki Gunma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Kadekawa","sequence":"additional","affiliation":[{"name":"Southern Knights' Laboratory LLP  Okinawa"},{"name":"Department of Urology Okinawa Kyodo Hospital  Naha"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Ashitomi","sequence":"additional","affiliation":[{"name":"Southern Knights' Laboratory LLP  Okinawa"},{"name":"Department of Urology Okinawa Hokubu Hospital  Nago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Nishijima","sequence":"additional","affiliation":[{"name":"Southern Knights' Laboratory LLP  Okinawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimio","family":"Sugaya","sequence":"additional","affiliation":[{"name":"Southern Knights' Laboratory LLP  Okinawa"},{"name":"Department of Urology Kitakami Central Hospital  Chatan Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.03.139"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v27.i1.30"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2003.11.002"},{"key":"e_1_2_7_5_1","first-page":"63","article-title":"Management of men diagnosed with chronic prostatitis\/chronic pelvic pain syndrome who have failed traditional management","volume":"9","author":"Nickel JC","year":"2007","journal-title":"Rev. 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