{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:12:39Z","timestamp":1789909959259,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T00:00:00Z","timestamp":1405382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine urinary nerve growth factor before and after dutasteride treatment, and to analyze correlations between clinical parameters and change of urinary nerve growth factor in patients with benign prostatic enlargement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively studied 30 patients with benign prostatic enlargement who had not been satisfied with \u03b1\u2010adrenergic antagonist monotherapy for more than 3 months. Before and 24 weeks after dutasteride add\u2010on treatment, we assessed <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternational <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rostate <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ymptom <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>core, prostatic volume, filling cystometry and pressure\u2010flow study. Urinary nerve growth factor was measured by enzyme\u2010linked immunosorbent assay, and normalized to the urinary creatinine (nerve growth factor\/creatinine) before and 24 weeks after dutasteride add\u2010on treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In baseline characteristics before dutasteride, there was no significant correlation between urinary nerve growth factor\/creatinine and any clinical parameters including age, <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternational <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rostate <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ymptom <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>core, prostatic volume, presence of detrusor overactivity, detrusor pressure at maximum flow rate, bladder outlet obstruction index or bladder contractility index. Dutasteride significantly reduced prostatic volume (from 68\u2009\u00b1\u200931\u2009mL to 49\u2009\u00b1\u200928\u2009mL) and improved <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternational <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rostate <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ymptom <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>core (from 17.2\u2009\u00b1\u20098.7 to 13.1\u2009\u00b1\u20096.8), storage (from 8.0\u2009\u00b1\u20094.3 to 6.0\u2009\u00b1\u20092.9) and voiding symptom subscore of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternational <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rostate <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ymptom <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>core (from 9.3\u2009\u00b1\u20095.7 to 7.1\u2009\u00b1\u20094.5). In urodynamic study, detrusor pressure at maximum flow rate (from 77\u2009\u00b1\u200932\u2009cmH<jats:sub>2<\/jats:sub>O to 59\u2009\u00b1\u200924\u2009cmH<jats:sub>2<\/jats:sub>O) and bladder outlet obstruction index (from 62\u2009\u00b1\u200932 to 42\u2009\u00b1\u200927) were significantly decreased after dutasteride treatment. Urinary nerve growth factor\/creatinine was significantly decreased after dutasteride from 2.61\u2009\u00b1\u20092.50 to 1.64\u2009\u00b1\u20091.68. The change of urinary nerve growth factor\/creatinine significantly correlated only with the change of prostatic volume (<jats:italic>r<\/jats:italic>\u2009=\u20090.38) and bladder outlet obstruction index (<jats:italic>r<\/jats:italic>\u2009=\u20090.36).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Urinary nerve growth factor decreases in association with reduction of prostatic volume and relief of bladder outlet obstruction. Urinary nerve growth factor might be useful as a biomarker to monitor the improvement of bladder outlet obstruction in patients with benign prostatic enlargement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12570","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T19:06:54Z","timestamp":1405451214000},"page":"1258-1262","source":"Crossref","is-referenced-by-count":13,"title":["Decreased urinary nerve growth factor reflects prostatic volume reduction and relief of outlet obstruction in patients with benign prostatic enlargement treated with dutasteride"],"prefix":"10.1111","volume":"21","author":[{"given":"Naoki","family":"Wada","sequence":"first","affiliation":[{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University  Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University  Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University  Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumi","family":"Hashizume","sequence":"additional","affiliation":[{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University  Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Kakizaki","sequence":"additional","affiliation":[{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University  Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0679-68"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21022"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2005.01140.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.01.069"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20741"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08380.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08851.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08675.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2009.37"},{"key":"e_1_2_7_11_1","first-page":"677","article-title":"The effect of dutasteride on voiding and storage symptoms in men with benign prostatic hyperplasia","volume":"56","author":"Tsukamoto T","year":"2010","journal-title":"Acta Urol. 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