{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:27:51Z","timestamp":1767652071405},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the efficacy and safety of onabotulinumtoxin<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>otox) injection into the bladder wall for the treatment of neurogenic detrusor overactivity secondary to spinal cord injury in Japanese patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese spinal cord injury patients with cystometrically confirmed neurogenic detrusor overactivity who experienced urinary incontinence at least once a week either because they were refractory to anticholinergics or had to discontinue treatment because of adverse events. Patients received 200 units of onabotulinumtoxin<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> injected into the bladder wall after a 2\u2010week washout of anticholinergics, and urodynamic variables were assessed before and 1\u2009month after injection. Catheterization and urinary incontinence data, as well as International Consultation on Incontinence Questionnaire \u2013 Short Form scores, were assessed before injection and every month thereafter until the cessation of treatment effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study enrolled 19 patients (13 men, six women, age range 22\u201367\u2009years). One month after injection, the mean number of urinary incontinence episodes decreased from 4.3 to 1.5\u2009times\/day (<jats:italic>P<\/jats:italic>\u2009=\u20090.004), and the maximum cystometric capacity increased from 100\u2009mL to 296\u2009mL (<jats:italic>P<\/jats:italic>\u2009=\u20090.0004). The rate of effective cases whose daily urinary incontinence frequency was decreased to less than 50% was 74%. The duration of efficacy without anticholinergic medication ranged from 3 to 12\u2009months (median 8.5\u2009months). Clinically significant adverse events were not observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present findings show the efficacy and tolerability of onabotulinumtoxinA injection for the treatment of neurogenic detrusor overactivity in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese spinal cord injury patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12668","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T07:24:09Z","timestamp":1416295449000},"page":"306-309","source":"Crossref","is-referenced-by-count":10,"title":["Botulinum toxin\u2009<scp>A<\/scp> injection for the treatment of neurogenic detrusor overactivity secondary to spinal cord injury: Multi\u2010institutional experience in <scp>J<\/scp>apan"],"prefix":"10.1111","volume":"22","author":[{"given":"Atsushi","family":"Sengoku","sequence":"first","affiliation":[{"name":"Department of Urology Hyogo Rehabilitation Center Hospital  Kobe Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kikuo","family":"Okamura","sequence":"additional","affiliation":[{"name":"Department of Urology National Center for Geriatrics and Gerontology  Obu Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasusuke","family":"Kimoto","sequence":"additional","affiliation":[{"name":"Department of Urology Spinal Injuries Center  Iizuka Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takatoshi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Urology Kainan Municipal Hospital  Kainan Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashige","family":"Namima","sequence":"additional","affiliation":[{"name":"Department of Urology Tohoku Rosai Hospital  Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Yamanishi","sequence":"additional","affiliation":[{"name":"Department of Urology Dokkyo Medical University  Mibu Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruhiko","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Urology Kawasaki Medical School  Kurashiki Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Akino","sequence":"additional","affiliation":[{"name":"Department of Urology University of Fukui  Eiheiji Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Urology Aoyama Hospital Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67283-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000162035.73977.1c"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365590601068835"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.01.125"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.07.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.02.004"},{"key":"e_1_2_8_8_1","unstructured":"U.S. Food and Drug Administration.FDA approves Botox to treat specific form of urinary incontinence.2011. 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