{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T16:43:27Z","timestamp":1717692207049},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T00:00:00Z","timestamp":1421193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine whether diabetes mellitus\u2010 and diuresis\u2010induced alterations in the bladder can be reversed in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male Sprague\u2013Dawley rats were randomly distributed into eight groups (<jats:italic>n<\/jats:italic>\u2009=\u200916 per group): 3\u2009weeks and 11\u2009weeks age\u2010matched controls, 3\u2009weeks and 11\u2009weeks after streptozotocin\u2010induced diabetes mellitus, 3\u2009weeks after diabetes mellitus induction then treated with insulin for 8\u2009weeks, 3\u2009weeks and 11\u2009weeks after 5% sucrose\u2010induced diuresis, and 3\u2009weeks after 5% sucrose\u2010induced diuresis followed by removal of 5% sucrose for 8\u2009weeks. Bodyweight, blood glucose and glycated hemoglobin A1c were monitored. At the designated time\u2010points, 24\u2010h urinary habits were examined, and cystometry was carried out in half of the animals. The bladders from the remaining animals were harvested for histological examination, and quantification of smooth muscle, urothelium and collagen components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Insulin treatment reversed hyperglycemia and polyuria in diabetic animals successfully, which was shown by normalization of blood glucose, glycated hemoglobin A1c and 24\u2010h urinary habits. Subsequently, bodyweight, bladder weight and percentage change of bladder components (smooth muscle, collagen, urothelium) in total bladder cross\u2010sectional area were reversed to almost normal levels, and the bladder dysfunction was mostly reversed by 8\u2009weeks of glycemic control, seen in the cystometry study. Similar alterations and reversed effects were seen in diuretic rats without and with 5% sucrose removal, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Short\u2010term (3\u2010week induction) diabetes\u2010 and polyuria\u2010induced functional and morphological alterations of the bladder can mostly be reversed in rats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12695","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T02:43:12Z","timestamp":1421289792000},"page":"410-415","source":"Crossref","is-referenced-by-count":15,"title":["Short\u2010term diabetes\u2010 and diuresis\u2010induced alterations of the bladder are mostly reversible in rats"],"prefix":"10.1111","volume":"22","author":[{"given":"Nan","family":"Xiao","sequence":"first","affiliation":[{"name":"Urology Institute, University Hospitals Case Medical Center and Department of Urology Case Western Reserve University School of Medicine Cleveland OH USA"},{"name":"The Second Hospital of Lanzhou University Lanzhou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yexiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Urology Institute, University Hospitals Case Medical Center and Department of Urology Case Western Reserve University School of Medicine Cleveland OH USA"},{"name":"The First Affiliated Hospital of China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kavran","sequence":"additional","affiliation":[{"name":"Urology Institute, University Hospitals Case Medical Center and Department of Urology Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania A","family":"Elrashidy","sequence":"additional","affiliation":[{"name":"Urology Institute, University Hospitals Case Medical Center and Department of Urology Case Western Reserve University School of Medicine Cleveland OH USA"},{"name":"Department of Biochemistry, Faculty of Pharmacy Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiming","family":"Liu","sequence":"additional","affiliation":[{"name":"Urology Institute, University Hospitals Case Medical Center and Department of Urology Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-2-318"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199502000-00013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.3760\/cma.j.issn.0366-6999.20132407","article-title":"Diabetic bladder dysfunction","volume":"127","author":"Liu G","year":"2014","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.08.070"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.29.11.374"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.04.062"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(06)00582-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00917.2005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36546-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655999750017059"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(91)90454-E"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.6.819"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.222"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.10.027"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.06.090"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20543"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00654.2005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1991.260.5.C1085"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0022-5347(17)50253-0","article-title":"Smooth muscle cell hypertrophy and hyperplasia in the rat detrusor after short\u2010time infravesical outflow obstruction","volume":"131","author":"Uvelius B","year":"1984","journal-title":"J. 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