{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:24:16Z","timestamp":1788668656951,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T00:00:00Z","timestamp":1427068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effects of transrectal compression of the prostate for intra\u2010operative prostatic swelling and intraprostatic point shift during high\u2010intensity focused ultrasound treatment of localized prostate cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients treated with whole\u2010gland high\u2010intensity focused ultrasound as primary monotherapy for localized prostate cancer were enrolled in the study. Using the standard and compression method, the volumes of degassed water in the balloon covering the high\u2010intensity focused ultrasound probe were 50 mL and 80\u2013160 mL, respectively. To identify prostatic swelling and shift during high\u2010intensity focused ultrasound and the volume occupied by the non\u2010enhanced area, three\u2010dimensional prostate models were reconstructed using ultrasound and contrast\u2010enhanced magnetic resonance imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In comparison with the standard (<jats:italic>n<\/jats:italic>\u2009=\u200940) and compression (<jats:italic>n<\/jats:italic>\u2009=\u200948) methods, intraoperative increase in the prostate volume (21% <jats:italic>vs<\/jats:italic> 5.3%; <jats:italic>P<\/jats:italic>\u2009=\u20090.044), intraprostatic point shift (4\u2009mm <jats:italic>vs<\/jats:italic> 2\u2009mm, <jats:italic>P<\/jats:italic>\u2009=\u20090.040 in the transition zone; 3\u2009mm <jats:italic>vs<\/jats:italic> 0\u2009mm; <jats:italic>P<\/jats:italic>\u2009=\u20090.001 in the peripheral zone) and the volume occupied by the non\u2010enhanced area (89% <jats:italic>vs<\/jats:italic> 96%; <jats:italic>P<\/jats:italic>\u2009=\u20090.001) were significantly suppressed. The biochemical disease\u2010free survival rate in patients treated using the compression method was significantly improved relative to the standard method (92.6% <jats:italic>vs<\/jats:italic> 76.5%; <jats:italic>P<\/jats:italic>\u2009=\u20090.038). Regarding complications, there was no significant difference in the rate of urethral stricture (<jats:italic>P<\/jats:italic>\u2009=\u20090.9), urinary tract infection (<jats:italic>P<\/jats:italic>\u2009=\u20090.9), incontinence (<jats:italic>P<\/jats:italic>\u2009=\u20090.3), erectile dysfunction (<jats:italic>P<\/jats:italic>\u2009=\u20090.9) or recto\u2010urethral fistula between the patients treated using the standard and compression methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intraoperative transrectal compression suppresses intraoperative increase in the prostate volume and intraprostatic point shift during high\u2010intensity focused ultrasound, having the potential to achieve precise whole\u2010gland and lesion\u2010targeted focal therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12747","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T21:17:10Z","timestamp":1427231830000},"page":"563-571","source":"Crossref","is-referenced-by-count":14,"title":["Morphological analysis of the effects of intraoperative transrectal compression of the prostate during high\u2010intensity focused ultrasound for localized prostate cancer"],"prefix":"10.1111","volume":"22","author":[{"given":"Sunao","family":"Shoji","sequence":"first","affiliation":[{"name":"Department of Urology Tokai University Hachioji Hospital  Hachioji Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Radiology Tokai University Hachioji Hospital  Hachioji Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Nakamoto","sequence":"additional","affiliation":[{"name":"Department of Radiology Osaka University Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Radiology Osaka University Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Fujikawa","sequence":"additional","affiliation":[{"name":"Department of Radiology Tokai University Hachioji Hospital  Hachioji Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Radiology Tokai University Hachioji Hospital  Hachioji Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Tomonaga","sequence":"additional","affiliation":[{"name":"Department of Urology Tokai University Hachioji Hospital  Hachioji Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayura","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Urology Tokai University Hachioji Hospital  Hachioji Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Terachi","sequence":"additional","affiliation":[{"name":"Department of Urology Tokai University School of Medicine  Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyoaki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Urology Tokai University Hachioji Hospital  Hachioji Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,23]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"3346","article-title":"Effect of high\u2010intensity focused ultrasound on human prostate cancer in vivo","volume":"55","author":"Madersbacher S","year":"1995","journal-title":"Cancer Res."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-8266(99)00005-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2000.14.519"},{"key":"e_1_2_7_5_1","first-page":"179","article-title":"High\u2010intensity focused ultrasound in prostate cancer: results after 3 years","volume":"4","author":"Chaussy C","year":"2000","journal-title":"Mol. 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