{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:42:21Z","timestamp":1762980141584},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T00:00:00Z","timestamp":1426550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the role of prostate volume assessed at final pathology in the risk of biochemical recurrence in patients with clinically localized prostate cancer treated with radical prostatectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall, 5637 patients treated with radical prostatectomy between January 1993 and August 2013 were identified. Multivariable Cox regression analyses tested the association between prostate volume and biochemical recurrence in the overall population and after stratifying patients according to the D'Amico risk groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean (median) prostate volume was 50.61\u2009mL (46\u2009mL). When patients were stratified according to D'Amico risk groups, mean (median) prostate volume was 51.7\u2009mL (48\u2009mL), 49.8\u2009mL (45\u2009mL) and 50.6\u2009mL (46\u2009mL) in low\u2010, intermediate\u2010, and high\u2010risk prostate cancer, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.04). Overall, the 5\u2010year biochemical recurrence\u2010free survival rate was 87.9%. In multivariable Cox regression analyses, prostate volume was associated with a lower risk of biochemical recurrence (hazard ratio 0.99, 95% confidence interval 0.99\u20131.00), after accounting for disease characteristics. However, when patients were stratified according to D'Amico risk groups, prostate volume represented an independent predictor of biochemical recurrence only in individuals with intermediate\u2010risk disease (hazard ratio 0.99, 95% confidence interval 0.99\u20131.00). Conversely, prostate volume was not associated with the risk of experiencing biochemical recurrence in patients with low\u2010 and high\u2010risk disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Smaller prostates are associated with increased risk of biochemical recurrence after surgery only in men with intermediate\u2010risk disease. In this category, the preoperative assessment of prostate volume might be helpful in order to identify patients at higher risk of biochemical recurrence after surgery. Additionally, prostate volume might be used to individualize follow\u2010up schedules after radical prostatectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12748","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T00:32:08Z","timestamp":1426638728000},"page":"555-561","source":"Crossref","is-referenced-by-count":15,"title":["Importance of prostate volume in the stratification of patients with intermediate\u2010risk prostate cancer"],"prefix":"10.1111","volume":"22","author":[{"given":"Marco","family":"Moschini","sequence":"first","affiliation":[{"name":"Unit of Urology\/Division of Oncology IRCCS Ospedale San Raffaele, Urological Research Institute  Milan Italy"},{"name":"Research Doctorate Program in Urology Magna Graecia University  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Gandaglia","sequence":"additional","affiliation":[{"name":"Unit of Urology\/Division of Oncology IRCCS Ospedale San Raffaele, Urological Research Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazareno","family":"Suardi","sequence":"additional","affiliation":[{"name":"Unit of Urology\/Division of Oncology IRCCS Ospedale San Raffaele, Urological Research Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Fossati","sequence":"additional","affiliation":[{"name":"Unit of Urology\/Division of Oncology IRCCS Ospedale San Raffaele, Urological Research Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Cucchiara","sequence":"additional","affiliation":[{"name":"Unit of Urology\/Division of Oncology IRCCS Ospedale San Raffaele, Urological Research Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco","family":"Damiano","sequence":"additional","affiliation":[{"name":"Research Doctorate Program in Urology Magna Graecia University  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Cantiello","sequence":"additional","affiliation":[{"name":"Research Doctorate Program in Urology Magna Graecia University  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrokh F","family":"Shariat","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Vienna and General Hospital  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Montorsi","sequence":"additional","affiliation":[{"name":"Unit of Urology\/Division of Oncology IRCCS Ospedale San Raffaele, Urological Research Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Briganti","sequence":"additional","affiliation":[{"name":"Unit of Urology\/Division of Oncology IRCCS Ospedale San Raffaele, Urological Research Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21208"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.09.046"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.11.969"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01441-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.11.007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.07.034"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12703"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.04.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.09.022"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.525"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00228-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-14-43"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2003.04361.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPPHGXDI94SGAC"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000020255"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.01.050"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.10.044"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(02)00031-3"},{"key":"e_1_2_7_20_1","first-page":"13","article-title":"The American Joint Committee on Cancer: updating the strategies in cancer staging","volume":"87","author":"Greene FL","year":"2002","journal-title":"Bull. Am. Coll. Surg."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.04.006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.03.037"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.07.104"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000062674.43964.d0"},{"key":"e_1_2_7_25_1","first-page":"4683","article-title":"Human prostate cancer and benign prostatic hyperplasia: molecular dissection by gene expression profiling","volume":"61","author":"Luo J","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28609"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2014.07.007"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.01.032"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.09.039"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.10.010"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiju.12748","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.12748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T13:55:08Z","timestamp":1696254908000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.12748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,17]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/iju.12748"],"URL":"https:\/\/doi.org\/10.1111\/iju.12748","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,17]]}}}