{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:58:39Z","timestamp":1771232319593,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T00:00:00Z","timestamp":1428969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyze the urothelial responses to mitomycin\u2009C treatment after urethral injury in rats, as the urothelium might play a role in the pathogenesis of urethral stricture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male Sprague\u2013Dawley rats were divided into four groups (<jats:italic>n<\/jats:italic>\u2009=\u20095\/group): negative control, positive control without further treatment, experimental control treated with sodium hyaluronate and sodium carboxymethylcellulose, and experimental treated with mitomycin\u2009C after internal urethrotomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with negative controls, positive controls showed a significant increase in cell proliferation and DNA damage accompanied by a considerable decrease in DNA repair in the urothelium, which resulted in urethral stricture. Experimental controls showed a significant increase in cell proliferation, DNA damage and DNA repair compared with negative controls. The mitomycin\u2009C\u2010treated group showed a significant decrease in cell proliferation and DNA damage, but a considerable increase in DNA repair compared with the positive and experimental control groups. DNA damage was immediately increased after urethral injury, but DNA repair and cell proliferation showed belated and upregulated expression after mitomycin\u2009C treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mitomycin\u2009C could induce healthy re\u2010epithelialization without severe damage in the urothelium. This finding might support the possibility of using mitomycin\u2009C as an adjuvant therapy for urethral strictures, and it might also suggest a urothelial role in the process of urethral stricture after urethral injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12780","type":"journal-article","created":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T10:47:19Z","timestamp":1429008439000},"page":"702-709","source":"Crossref","is-referenced-by-count":6,"title":["Morphological effects of mitomycin C on urothelial responses to experimentally\u2010induced urethral stricture in rats"],"prefix":"10.1111","volume":"22","author":[{"given":"In Youb","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Anatomy, College of Medicine Chosun University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Nam","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoulpaik Hospital Inje University College of Medicine  Seoul"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun\u2010Ouck","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology Chonnam National University Medical School  Gwangju"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misook","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Nursing, School of Natural Science Songwon University  Gwangju"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010Sik","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine Jeju National University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Hee","family":"Maeng","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Jeju National University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Pil","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine Jeju National University  Jeju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,14]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1055","volume-title":"Campbell\u2010Walsh Urology","author":"Jordan GH","year":"2007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.05.023"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2004.00959.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.11.038"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2009.50.8.805"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr030117g"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/ctrv.2000.0202"},{"key":"e_1_2_8_9_1","first-page":"27","article-title":"Urothelial changes induced by therapeutic procedures for bladder cancer","volume":"27","author":"Mazzucchelli R","year":"2005","journal-title":"A review. 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