{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T02:44:57Z","timestamp":1768272297251,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the prognostic value of preoperative pyuria in patients with non\u2010muscle\u2010invasive bladder cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed data from 237 patients diagnosed with non\u2010muscle\u2010invasive bladder cancer. Pyuria was defined as urine containing \u22655 white blood cells per high power field. The association between clinicopathological factors and recurrence was assessed by Cox univariate and multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preoperative pyuria was found in 116 (49.0%) patients. Pyuria was significantly associated with advanced age, positive cytology, multiple tumors, large tumor size, non\u2010papillary tumors, T1 tumors and high\u2010grade tumors. In univariate analysis of the entire patient population, pyuria, positive urine cytology, multiple tumors, pT1 tumors and no bacillus Calmette\u2013Gu\u00e9rin were significantly associated with recurrence. Multivariate analysis showed that pyuria was an independent predictor of recurrence (hazard ratio 3.332, 95% confidence interval 2.052\u20135.410; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), along with positive urine cytology, multiple tumors and no bacillus Calmette\u2013Gu\u00e9rin therapy. Subanalysis of the patients who underwent bacillus Calmette\u2013Gu\u00e9rin therapy also showed that pyuria was an independent predictor of recurrence (hazard ratio 2.062, 95% confidence interval 1.085\u20133.918, <jats:italic>P<\/jats:italic>\u2009=\u20090.027). The 2\u2010year recurrence\u2010free survival rate for patients with pyuria was significantly lower than for patients without pyuria (65.5% <jats:italic>vs<\/jats:italic> 80.7%; <jats:italic>P<\/jats:italic>\u2009=\u20090.027).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preoperative pyuria seems to be significantly associated with recurrence in patients with non\u2010muscle\u2010invasive bladder cancer, and it might be a useful predictor for recurrence after bacillus Calmette\u2013Gu\u00e9rin therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12788","type":"journal-article","created":{"date-parts":[[2015,4,25]],"date-time":"2015-04-25T00:13:01Z","timestamp":1429920781000},"page":"645-649","source":"Crossref","is-referenced-by-count":20,"title":["Prognostic value of preoperative pyuria in patients with non\u2010muscle\u2010invasive bladder cancer"],"prefix":"10.1111","volume":"22","author":[{"given":"Naoya","family":"Satake","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Ohori","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26123"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1998.00628.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.031"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2010.02678.x"},{"issue":"1","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000475205","article-title":"Practical approaches to the prevention and treatment of adverse reactions to BCG","volume":"27","author":"Meijden AP","year":"1995","journal-title":"Eur. 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