{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:21:52Z","timestamp":1774362112585,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,5]],"date-time":"2015-07-05T00:00:00Z","timestamp":1436054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyze the efficacy of hyperbaric oxygen for the treatment of radiation\u2010induced hemorrhagic cystitis and to identify factors associated with successful treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical records from 176 patients with refractory radiation\u2010induced hemorrhagic cystitis treated at the Portuguese Navy Center for Underwater and Hyperbaric Medicine, during a 15\u2010year period, were retrospectively analyzed. Evolution of macroscopic hematuria was used to analyze treatment efficacy and correlated with other external variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From a total of 176 treated patients, 23.9% evidenced other radiation\u2010induced soft tissue lesions. After an average on 37 sessions, 89.8% of patients showed resolution of hematuria, with only 1.7% of adverse events. In our sample, hematuria resolution after treatment with hyperbaric oxygen was statistically associated to the need for transfusion therapy (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.026) and the number of sessions of hyperbaric oxygen (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.042). No relationship was found with the remaining variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Refractory radiation\u2010induced hemorrhagic cystitis can be successfully and safely treated with hyperbaric oxygen. Treatment effectiveness seems to be correlated with the need for transfusion therapy and the number of sessions performed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12857","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T04:05:44Z","timestamp":1436155544000},"page":"962-966","source":"Crossref","is-referenced-by-count":34,"title":["Hyperbaric oxygen therapy for refractory radiation\u2010induced hemorrhagic cystitis"],"prefix":"10.1111","volume":"22","author":[{"given":"Tiago M","family":"Ribeiro de Oliveira","sequence":"first","affiliation":[{"name":"Underwater and Hyperbaric Medicine Center Portuguese Navy Lisbon Portugal"},{"name":"Department of Urology Hospital de Santa Maria Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f3nio J","family":"Carmelo Rom\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital de Santa Maria Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco M","family":"Gamito Guerreiro","sequence":"additional","affiliation":[{"name":"Underwater and Hyperbaric Medicine Center Portuguese Navy Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e9 M","family":"Matos Lopes","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital de Santa Maria Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181b12f99"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860310014660"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860310012301"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860310014408"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860410030661"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860310014426"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860310014417"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24354"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5525"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(18)30354-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1278"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000049760"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hch074"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.07.138"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.10.037"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)41016-0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2008.0432"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-002-0069-5"},{"key":"e_1_2_8_20_1","first-page":"CD004123","article-title":"Hyperbaric oxygen therapy for chronic wounds","volume":"18","author":"Kranke P","year":"2004","journal-title":"Cochrane Database Syst. 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