{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:10:57Z","timestamp":1782439857966,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T00:00:00Z","timestamp":1438819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate longitudinal changes in urinary function and quality of life, and the oncological outcomes of patients treated with urethra\u2010sparing high\u2010intensity focused ultrasound for localized prostate cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with negative findings in the urethra and the anterior urethral zone using transrectal ultrasound\u2010guided targeted biopsies, and magnetic resonance imaging, received urethra\u2010sparing or whole\u2010gland high\u2010intensity focused ultrasound as the primary therapy for localized prostate cancer without transurethral resection of the prostate. Longitudinal changes in urinary function and quality of life, and the oncological outcomes of the patients were analyzed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up times for urethra\u2010sparing and whole\u2010gland high\u2010intensity focused ultrasound were 36 and 30\u00a0months, respectively. Comparing the patients treated with urethra\u2010sparing high\u2010intensity focused ultrasound (<jats:italic>n<\/jats:italic>\u00a0=\u00a045) with those treated with whole\u2010gland high\u2010intensity focused ultrasound (<jats:italic>n<\/jats:italic>\u00a0=\u00a065), there were significant differences in the International Prostate Symptom Score (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.014) at 3\u00a0months, International Prostate Symptom Score quality of life (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.033) at 3\u00a0months, maximum urinary flow rate (mL\/s; at 3\u00a0months, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.010; at 6\u00a0months, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.038) and residual urine volume (mL; at 3\u00a0months, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001; at 6\u00a0months, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.016; at 12\u00a0months, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.028). For quality of life, there were significant differences in Functional Assessment of Cancer Therapy \u2013 General (at 3\u00a0months, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.022) and Functional Assessment of Cancer Therapy \u2013 Prostate (at 3\u00a0months, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.028; at 6\u00a0months, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.034). There were no significant differences in oncological outcomes regarding negative biopsy rates on follow up (91% <jats:italic>vs<\/jats:italic> 92%; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.8) or biochemical disease\u2010free survival rates (86.7% <jats:italic>vs<\/jats:italic> 89.2%; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Urethra\u2010sparing high\u2010intensity focused ultrasound might prevent prolonged bladder outlet obstruction, and could be a treatment option for localized prostate cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12876","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T19:51:17Z","timestamp":1438890677000},"page":"1043-1049","source":"Crossref","is-referenced-by-count":21,"title":["Urethra\u2010sparing high\u2010intensity focused ultrasound for localized prostate cancer: Functional and 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