{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:15:12Z","timestamp":1696317312819},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chang-Gung University Hospital","award":["CMRPG370821-23"],"award-info":[{"award-number":["CMRPG370821-23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To create a mouse model pertaining to mesh\u2010elicited suburethral functional and histological changes after vaginal distention, and to examine the possible mechanism behind these complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We divided 48 virgin female C57BL\/6 mice into four groups: vaginal distention alone, vaginal distention followed by prolene mesh implantation, vaginal distention followed by sham mesh implantation and untreated control. Each group was divided into two subgroups for conscious cystometrogram, leak\u2010point pressure testing and harvesting of suburethral tissue 4 or 10\u00a0days after vaginal distention. The suburethral tissues underwent immunohistochemistry and western blot analysis of nerve growth factor, matrix metalloproteinase\u00a02 and tissue inhibitor of metalloproteinase\u00a02. Urodynamic results were compared among groups using one way ANOVA, with Tukey's multiple comparisons post\u2010test for pair wise comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Leak\u2010point pressure in the vaginal distention and vaginal distention +\u00a0sham mesh groups were significantly lower than in the control and vaginal distention +\u00a0mesh groups at day 4. Leak\u2010point pressure in the vaginal distention +\u00a0mesh group were significantly higher than in the other three groups at both day 4 and 10. Immunohistochemistry and western blotting showed increased matrix metalloproteinase\u00a02 and tissue inhibitor of metalloproteinase\u00a02 levels in the vaginal distention\u00a0+\u00a0mesh group at day\u00a04 and 10. Furthermore, nerve growth factor expression was increased in the same area and same group at 10\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased suburethral tissue matrix metalloproteinase and nerve growth factor expression might be related to tissue remodeling after prolene mesh implantation for stress urinary incontinence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12888","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T20:35:21Z","timestamp":1441226121000},"page":"1068-1074","source":"Crossref","is-referenced-by-count":4,"title":["Effect of suburethral prolene mesh for suburethral function and histology in a stress urinary incontinence mouse model"],"prefix":"10.1111","volume":"22","author":[{"given":"Yi\u2010Hao","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Urogynecology Department of Obstetrics and Gynecology Linkou Medical Center Chang Gung Memorial Hospital Chang Gung University College of Medicine Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex C","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Urogynecology Department of Obstetrics and Gynecology Linkou Medical Center Chang Gung Memorial Hospital Chang Gung University College of Medicine Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Urogynecology Department of Obstetrics and Gynecology Linkou Medical Center Chang Gung Memorial Hospital Chang Gung University College of Medicine Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao\u2010Chien","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Urogynecology Department of Obstetrics and Gynecology Linkou Medical Center Chang Gung Memorial Hospital Chang Gung University College of Medicine Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Chung","family":"Liang","sequence":"additional","affiliation":[{"name":"Division of Urogynecology Department of Obstetrics and Gynecology Linkou Medical Center Chang Gung Memorial Hospital Chang Gung University College of Medicine Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firouz","family":"Daneshgari","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospitals Case Medical Center, Case Western Reserve University Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20798"},{"issue":"3","key":"e_1_2_8_3_1","first-page":"S3","article-title":"The definition, prevalence, and risk factors for stress urinary incontinence","volume":"6","author":"Luber KM","year":"2004","journal-title":"Rev. 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