{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:51:36Z","timestamp":1792428696183,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy of a second injection of the same toxin versus switching to a different botulinum toxin\u00a0A after failure of a first detrusor injection in patients with neurogenic detrusor overactivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The charts of all patients who underwent detrusor injections of botulinum toxin\u00a0A (either abobotulinumtoxinA or onabotulinumtoxinA) for the management of neurogenic detrusor overactivity at a single institution were retrospectively reviewed. Patients in whom a first detrusor injection had failed were included in the present study. They were managed by a second injection of the same toxin at the same dosage or by a new detrusor injection using a different botulinum toxin\u00a0A. Success was defined as a resolution of urgency, urinary incontinence and detrusor overactivity in a patient self\u2010catheterizing seven times or less per 24\u00a0h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 58 patients were included for analysis. A toxin switch was carried out in 29 patients, whereas the other 29 patients received a reinjection of the same toxin at the same dose. The success rate was higher in patients who received a toxin switch (51.7% <jats:italic>vs<\/jats:italic> 24.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). Patients treated with a switch from abobotulinumtoxinA to onabotulinumtoxinA and those treated with a switch from onabotulinumtoxinA to abobotulinumtoxinA had similar success rates (52.9% <jats:italic>vs<\/jats:italic> 50%, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.88).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After failure of a first detrusor injection of botulinum toxin for neurogenic detrusor overactivity, a switch to a different toxin seems to be more effective than a second injection of the same toxin. The replacement of onabotulinumtoxin by abobotulinumtoxin or the reverse provides similar results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12950","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T10:16:58Z","timestamp":1442917018000},"page":"1160-1165","source":"Crossref","is-referenced-by-count":16,"title":["Failure of botulinum toxin injection for neurogenic detrusor overactivity: Switch of toxin versus second injection of the same toxin"],"prefix":"10.1111","volume":"22","author":[{"given":"Benoit","family":"Peyronnet","sequence":"first","affiliation":[{"name":"Department of Urology CHU Rangueil Toulouse France"},{"name":"Department of Urology CHU Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Castel\u2010Lacanal","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine CHU Rangueil Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"Manunta","sequence":"additional","affiliation":[{"name":"Department of Urology CHU Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Roumigui\u00e9","sequence":"additional","affiliation":[{"name":"Department of Urology CHU Rangueil Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Marque","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine CHU Rangueil Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Rischmann","sequence":"additional","affiliation":[{"name":"Department of Urology CHU Rangueil Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Gam\u00e9","sequence":"additional","affiliation":[{"name":"Department of Urology CHU Rangueil Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67283-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22631"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.purol.2013.09.020"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.02.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.07.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.01.125"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.07.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.purol.2012.10.006"},{"key":"e_1_2_7_10_1","unstructured":"PannekJ BlokB Castro\u2010DiazDet\u00a0al.EAU guidelines on neuro\u2010urology 2014. 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