{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:03:08Z","timestamp":1791644588277,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Iranian Ministry of Science, Research and Technology","award":["2011\/11\/10595"],"award-info":[{"award-number":["2011\/11\/10595"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effect of autologous muscle\u2010derived cells injection in the treatment of complicated stress urinary incontinence in female patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Female patients presenting with severe and complicated stress urinary incontinence secondary to the bladder neck and\/or urethral trauma or congenital epispadias (with or without exstrophy) were enrolled in this prospective study. They underwent transurethral injection of autologous muscle\u2010derived cells. In selected cases, another injection was given after 6 months, as per the surgeon's assessment. All patients were monitored for 1 year, and the effect of autologous muscle\u2010derived cells was evaluated by cough stress test, 1\u2010h pad test and Incontinence Impact Questionnaire\u2010short form score. A multichannel urodynamic study and maximum urethral closure pressure were carried out before and 12 months after the last treatment session. Cough stress test, 1\u2010h pad test and uroflowmetry were repeated 36 months after the last injection. Severity and occurrence of complications were recorded at each visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 10 patients who completed the study were monitored for 36 months. Three patients were cured, four had improved and three did not respond to the treatment. There was no major adverse effect related to the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Muscle\u2010derived cell therapy might represent a minimally\u2010invasive and a safe procedure in the treatment of patients with severe and complicated stress urinary incontinence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13097","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T18:34:09Z","timestamp":1460313249000},"page":"581-586","source":"Crossref","is-referenced-by-count":25,"title":["Effect of autologous muscle\u2010derived cells in the treatment of urinary incontinence in female patients with intrinsic sphincter deficiency and epispadias: A prospective study"],"prefix":"10.1111","volume":"23","author":[{"given":"Farzaneh","family":"Sharifiaghdas","sequence":"first","affiliation":[{"name":"Urology and Nephrology Research Center Shahid Labbafinejad Medical Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzam","family":"Tajalli","sequence":"additional","affiliation":[{"name":"Urology and Nephrology Research Center Shahid Labbafinejad Medical Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Taheri","sequence":"additional","affiliation":[{"name":"Urology and Nephrology Research Center Shahid Labbafinejad Medical Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Naji","sequence":"additional","affiliation":[{"name":"Urology and Nephrology Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Moghadasali","sequence":"additional","affiliation":[{"name":"Department of Stem Cells and Developmental Biology Cell Science Research Center Royan Institute for Stem Cell Biology and Technology Tehran Iran"},{"name":"Department of Regenerative Biomedicine Cell Science Research Center Royan Institute for Stem Cell Biology and Technology Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Aghdami","sequence":"additional","affiliation":[{"name":"Department of Regenerative Biomedicine Cell Science Research Center Royan Institute for Stem Cell Biology and Technology Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Baharvand","sequence":"additional","affiliation":[{"name":"Department of Stem Cells and Developmental Biology Cell Science Research Center Royan Institute for Stem Cell Biology and Technology Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vajihe","family":"Azimian","sequence":"additional","affiliation":[{"name":"Department of Regenerative Biomedicine Cell Science Research Center Royan Institute for Stem Cell Biology and Technology Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Jaroughi","sequence":"additional","affiliation":[{"name":"Department of Regenerative Biomedicine Cell Science Research Center Royan Institute for Stem Cell Biology and Technology Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"issue":"3","key":"e_1_2_8_2_1","first-page":"S3","article-title":"The definition, prevalence, and risk factors for stress urinary incontinence","volume":"6","author":"Luber KM","year":"2004","journal-title":"Rev. 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