{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T13:08:10Z","timestamp":1747141690012},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,24]],"date-time":"2016-04-24T00:00:00Z","timestamp":1461456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea Healthcare Technology R&D Project"},{"name":"Ministry for Health, Welfare & Family Affairs","award":["A110076"],"award-info":[{"award-number":["A110076"]}]},{"name":"Medical Research Center Grant","award":["2014R1A5A2009392"],"award-info":[{"award-number":["2014R1A5A2009392"]}]},{"name":"Korean Government (Ministry of Science, ICT and Future Planning)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the molecular events related to penile erection in the corpus cavernosum tissue of mice after electrical stimulation of the cavernous nerve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve\u2010week\u2010old male C57BL\/6 mice were used in this study. Electrical stimulation of the cavernous nerve was carried out to induce penile erection. Corpus cavernosum tissues were then harvested to determine the effect of nerve\u2010induced penile erection on signaling pathway involved in angiogenesis (vascular endothelial growth factor, hepatocyte growth factor, angiopoietin\u20101, matrix metalloproteinase\u00a02, and matrix metalloproteinase\u00a09), cell survival and proliferation (phosphatidylinositol 3\u2010kinase, phospho\u2010Akt\/Akt, and phospho\u2010ERK\/ERK), and tissue fibrosis (phospho\u2010Smad2\/Smad2, phospho\u2010Smad3\/Smad3, and plasminogen activator inhibitor\u20101).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cavernous nerve stimulation enhanced the expression of factors involved in angiogenesis (vascular endothelial growth factor, hepatocyte growth factor, angiopoietin\u20101, matrix metalloproteinase\u00a02, and metalloproteinase\u00a09), and activated intracellular signaling mediators related to cell survival and proliferation (phosphatidylinositol 3\u2010kinase, phospho\u2010Akt\/Akt, and phospho\u2010ERK\/ERK), while suppressing the pathways involved in tissue fibrosis (phospho\u2010Smad2\/Smad2, phospho\u2010Smad3\/Smad3, and plasminogen activator inhibitor\u20101).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Penile erection in mice is accompanied by the activation of a cascade of signaling pathways involved in angiogenesis, cell survival and proliferation, and antifibrosis. The present results might provide a theoretical and molecular basis for understanding the importance of penile rehabilitation and subsequent restoration of nocturnal or sexually\u2010mediated penile erections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13105","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T04:03:07Z","timestamp":1461556987000},"page":"614-622","source":"Crossref","is-referenced-by-count":10,"title":["Penile erection induces angiogenic, survival, and antifibrotic signals: molecular events associated with penile erection induced by cavernous nerve stimulation in mice"],"prefix":"10.1111","volume":"23","author":[{"given":"Mi\u2010Hye","family":"Kwon","sequence":"first","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology Inha University School of Medicine Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo\u2010Hwan","family":"Park","sequence":"additional","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology Inha University School of Medicine Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang\u2010Moon","family":"Song","sequence":"additional","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology Inha University School of Medicine Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalyan","family":"Ghatak","sequence":"additional","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology Inha University School of Medicine Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Limanjaya","sequence":"additional","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology Inha University School of Medicine Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Soo","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Urology Sungkyunkwan University School of Medicine Samsung Changwon Hospital Changwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyeon","family":"Ock","sequence":"additional","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology Inha University School of Medicine Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon\u2010Sun","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Medicine Inha University School of Medicine Incheon Korea"},{"name":"Inha Research Institute for Medical Sciences Inha University School of Medicine Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Kan","family":"Ryu","sequence":"additional","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology Inha University School of Medicine Incheon Korea"},{"name":"Inha Research Institute for Medical Sciences Inha University School of Medicine Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Kyu","family":"Suh","sequence":"additional","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology Inha University School of Medicine Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.004515"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)92168-Y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116220"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.135.2.191"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-004-0072-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12228"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2014.55.2.112"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07515.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000209518.58252.17"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.06.009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1714"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1715"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81817-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2012.10.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.12.027"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.10.016"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)69141-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2008.1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81813-9"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0354"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01925.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.1937"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12119"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-004-0705-x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2007.05.013"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1911"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.1.24"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.2.H552"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.00977.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01942.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.02049.x"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiju.13105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.13105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:59:18Z","timestamp":1695553158000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.13105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,24]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/iju.13105"],"URL":"https:\/\/doi.org\/10.1111\/iju.13105","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,24]]}}}