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Rotation of the testis and twisting of the spermatic cord rapidly leads to ischemia, resulting in a loss of germ cells. Thus, prompt diagnosis and urgent surgical intervention are required, but the subsequent release of the torsion induces reperfusion injury, which causes further damage to the ischemic testis. Testicular torsion\u2013detorsion (ischemia\u2013reperfusion) injury triggers the generation of reactive oxygen species, pro\u2010inflammatory cytokines, neutrophil recruitment, lipid peroxidation, anoxia and apoptosis, which carry a significant risk of subsequent infertility. Previously, the effects of numerous pharmacological agents and treatments have been evaluated to prevent testicular ischemia\u2013reperfusion injury in animal models. We propose a new treatment, especially postconditioning, to prevent adverse effects of ischemia\u2013reperfusion injury after testicular torsion\u2013detorsion.<\/jats:p>","DOI":"10.1111\/iju.13110","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T22:48:41Z","timestamp":1464130121000},"page":"454-463","source":"Crossref","is-referenced-by-count":85,"title":["Testicular torsion\u2013detorsion and potential therapeutic treatments: A possible role for ischemic postconditioning"],"prefix":"10.1111","volume":"23","author":[{"given":"Shogo","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Pharmacology Kochi Medical School Kochi University Nankoku Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Tsounapi","sequence":"additional","affiliation":[{"name":"Division of Urology Tottori University School of Medicine Yonago Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotios","family":"Dimitriadis","sequence":"additional","affiliation":[{"name":"Department of Urology School of Medicine Ioannina University Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youichirou","family":"Higashi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Kochi Medical School Kochi University Nankoku Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Kochi Medical School Kochi University Nankoku Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoaki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Kochi Medical School Kochi University Nankoku Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,23]]},"reference":[{"key":"e_1_2_23_2_1","first-page":"16","article-title":"Testicular torsion, oxidative stress and the role of antioxidant therapy","volume":"48","author":"Dokmeci D","year":"2006","journal-title":"Folia Med. 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