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The guidelines define interstitial cystitis by the presence of hypersensitive bladder symptoms (discomfort, pressure or pain in the bladder usually associated with urinary frequency and nocturia) and bladder pathology, after excluding other diseases explaining symptoms. Interstitial cystitis is further classified by bladder pathology; either Hunner type interstitial cystitis with Hunner lesions or non\u2010Hunner type interstitial cystitis with mucosal bleeding after distension in the absence of Hunner lesions. Hypersensitive bladder refers to a condition, where hypersensitive bladder symptoms are present, but bladder pathology or other explainable diseases are unproven. Interstitial cystitis and hypersensitive bladder severely affect patients' quality of life as a result of disabling symptoms and\/or comorbidities. Reported prevalence suggestive of these disorders varies greatly from 0.01% to &gt;6%. Pathophysiology would be an interaction of multiple factors including urothelial dysfunction, inflammation, neural hyperactivity, exogenous substances and extrabladder disorders. Definite diagnosis of interstitial cystitis and hypersensitive bladder requires cystoscopy with or without hydrodistension. Most of the therapeutic options lack a high level of evidence, leaving a few as recommended therapeutic options.<\/jats:p>","DOI":"10.1111\/iju.13118","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T21:40:50Z","timestamp":1464126050000},"page":"542-549","source":"Crossref","is-referenced-by-count":114,"title":["Clinical guidelines for interstitial cystitis and hypersensitive bladder updated in 2015"],"prefix":"10.1111","volume":"23","author":[{"given":"Yukio","family":"Homma","sequence":"first","affiliation":[{"name":"Department of Urology Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Urology Ueda Clinic Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Tomoe","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo 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