{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T07:51:40Z","timestamp":1758959500218},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T00:00:00Z","timestamp":1482537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Insulin\u2010like growth factor 2 is overexpressed in various cancers, and is associated with a poor prognosis. Also, it is known that insulin\u2010like growth factor 2 is an etiology of non\u2010islet cell tumor hypoglycemia. In this report, we describe a case of unexpected hypoglycemia caused by a dedifferentiated liposarcoma producing insulin\u2010like growth factor 2. A large mass in the retroperitoneum was detected in a 61\u2010year\u2010old man who complained of appetite loss. Despite having no history of diabetes mellitus, hypoglycemia suddenly occurred after admission, but oral glucose therapy was ineffective. After total parenteral nutrition, tumor resection was attempted, but failed as a result of rigid adhesion to the surrounding organs. The patient died of the disease 21 days after surgery. Pathological diagnosis at autopsy revealed dedifferentiated liposarcoma, and immunohistochemical staining showed that the tumor excreted insulin\u2010like growth factor 2. The possibility of an insulin\u2010like growth factor 2\u2010producing tumor should be taken into consideration when we encounter a patient with spontaneous hypoglycemia resistant to glucose substitution therapy.<\/jats:p>","DOI":"10.1111\/iju.13276","type":"journal-article","created":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T05:53:35Z","timestamp":1482645215000},"page":"162-165","source":"Crossref","is-referenced-by-count":3,"title":["Retroperitoneal liposarcoma excreting insulin\u2010like growth factor 2 that induced severe hypoglycemia"],"prefix":"10.1111","volume":"24","author":[{"given":"Takuma","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Urology Kagawa University Faculty of Medicine Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikio","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Urology Kagawa University Faculty of Medicine Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoki","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Urology Kagawa University Faculty of Medicine Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Department of Urology Kagawa University Faculty of Medicine Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Hirama","sequence":"additional","affiliation":[{"name":"Department of Urology Kagawa University Faculty of Medicine Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tsunemori","sequence":"additional","affiliation":[{"name":"Department of Urology Kagawa University Faculty of Medicine Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobufumi","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Urology Kagawa University Faculty of Medicine Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Imachi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kagawa University Faculty of Medicine Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kagawa University Faculty of Medicine Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Kushida","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kagawa University Faculty of Medicine Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Kakehi","sequence":"additional","affiliation":[{"name":"Department of Urology Kagawa University Faculty of Medicine Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-1012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.2014.869173"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-009-0815-x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-13-0231"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2006.05.003"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiju.13276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.13276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T12:21:00Z","timestamp":1696162860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.13276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,24]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/iju.13276"],"URL":"https:\/\/doi.org\/10.1111\/iju.13276","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,24]]}}}