{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:48:32Z","timestamp":1773215312688,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,2]],"date-time":"2017-04-02T00:00:00Z","timestamp":1491091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the predicting factors of therapeutic response to \u03b11\u2010blockers in patients with lower urinary tract symptoms associated with benign prostate enlargement based on a urodynamic study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective study involving 125 outpatients with <jats:styled-content style=\"fixed-case\">lower urinary tract symptoms<\/jats:styled-content> associated with <jats:styled-content style=\"fixed-case\">benign prostate enlargement<\/jats:styled-content>. They received 8\u00a0mg of silodosin for 12\u00a0months. International Prostate Symptom Score, <jats:styled-content style=\"fixed-case\">Overactive Bladder Symptom Score<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> International Prostate Symptom Score quality of life assessment<\/jats:styled-content>, and urodynamic study were used to assess subjective and objective symptoms. Patient age, prostate\u2010specific antigen level, prostate volume, <jats:styled-content style=\"fixed-case\">International Prostate Symptom Score<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> Overactive Bladder Symptom Score<\/jats:styled-content>, maximum flow rate and post\u2010void residual urine volume, and intravesical prostatic protrusion were investigated as potential parameters to predict the therapeutic response. Baseline parameters that influenced the improvement of <jats:styled-content style=\"fixed-case\">International Prostate Symptom Score<\/jats:styled-content> and bladder outlet obstruction were statistically analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 103 patients with mean age of 69.2\u00a0years and mean prostate volume of 46.8\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> were included in the analysis. A total of 39 patients (37.9%) showed insignificant improvement in <jats:styled-content style=\"fixed-case\">International Prostate Symptom Score<\/jats:styled-content> (&lt;25%), whereas 36 patients (35.0%) showed insufficient improvement in <jats:styled-content style=\"fixed-case\">bladder outlet obstruction<\/jats:styled-content> index (less than 25%). Prostate volume, maximum flow rate and <jats:styled-content style=\"fixed-case\">intravesical prostatic protrusion<\/jats:styled-content> were independent predictors of ineffective treatment. On multivariate logistic regression analysis, <jats:styled-content style=\"fixed-case\">intravesical prostatic protrusion<\/jats:styled-content> was found to be the only factor related to improvement of both <jats:styled-content style=\"fixed-case\">the International Prostate Symptom Score<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">bladder outlet obstruction<\/jats:styled-content>. Additionally, multiple linear regression analysis showed that <jats:styled-content style=\"fixed-case\">intravesical prostatic protrusion<\/jats:styled-content> was the only significant factor for predicting improvement of <jats:styled-content style=\"fixed-case\">the International Prostate Symptom Score<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.56, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and <jats:styled-content style=\"fixed-case\">bladder outlet obstruction<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.59, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">Intravesical prostatic protrusion<\/jats:styled-content> can be considered a useful predictor of therapeutic response to silodosin for subjective symptoms and <jats:styled-content style=\"fixed-case\">bladder outlet obstruction<\/jats:styled-content> in male patients with <jats:styled-content style=\"fixed-case\">lower urinary tract symptoms<\/jats:styled-content> associated with <jats:styled-content style=\"fixed-case\">benign prostate enlargement<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13333","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T00:13:56Z","timestamp":1491351236000},"page":"454-459","source":"Crossref","is-referenced-by-count":13,"title":["Intravesical prostatic protrusion can predict therapeutic response to silodosin in male patients with lower urinary tract symptoms"],"prefix":"10.1111","volume":"24","author":[{"given":"Yoshihisa","family":"Matsukawa","sequence":"first","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine Nagoya 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