{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:54:34Z","timestamp":1791644074261,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,18]],"date-time":"2017-06-18T00:00:00Z","timestamp":1497744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the efficacy of two \u03b11\u2010adrenoceptor antagonists with different affinities for \u03b11\u2010adrenoceptor subtypes, silodosin and naftopidil, in the treatment of premature ejaculation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, open\u2010label, multicenter trial. A total of 26 patients with untreated acquired premature ejaculation were enrolled. Premature ejaculation was defined based on the International Society for Sexual Medicine recommendation. Patients self\u2010administered on demand silodosin 4 mg or naftopidil 25 mg 1 h before intercourse, alternating drugs at least three times each. Clinical global impression change for premature ejaculation, premature ejaculation profile, and intravaginal ejaculation latency time were evaluated at baseline and during treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Due to clinical global impression change, 24 patients (92%) and 12 patients (46%) reported improvement in their own premature ejaculation problems under silodosin and nafitopidil administration, respectively. Silodosin treatment produced a significantly higher improvement rate compared with naftopidil (<jats:italic>P<\/jats:italic>= 0.0002). Objectively, silodosin significantly prolonged intravaginal ejaculation latency time compared with baseline and naftopidil (<jats:italic>P<\/jats:italic>&lt; 0.01). Mean intravaginal ejaculation latency times were 1.9, 4.1, and 7.6 min at baseline, control and with silodosin, respectively. The rate of reduced semen volume during silodosin treatment was higher than during naftopidil treatment. There were no adverse systemic effects in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Silodosin, a highly selective \u03b11A\u2010adrenoceptor antagonist, produces greater improvements in premature ejaculation profiles and related symptoms along with intravaginal ejaculation latency time in acquired premature ejaculation patients with or without erectile dysfunction. This result supports the clinical use of silodosin as an alternative treatment for premature ejaculation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13392","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T04:13:09Z","timestamp":1497845589000},"page":"626-631","source":"Crossref","is-referenced-by-count":23,"title":["Silodosin versus naftopidil in the treatment of premature ejaculation: A prospective multicenter trial"],"prefix":"10.1111","volume":"24","author":[{"given":"Yoshikazu","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Urology Sanjukai Hospital Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikazu","family":"Otani","sequence":"additional","affiliation":[{"name":"Department of Urology Chubu Rosai Hospital Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyasu","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Urology Nagano Red Cross Hospital Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Urology Araki Urologic Clinic Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Kondou","sequence":"additional","affiliation":[{"name":"Department of Urology Kyoritsu Hospital Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Matsukawa","sequence":"additional","affiliation":[{"name":"Department of Urology Takikawa Municipal Hospital Takikawa Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musashi","family":"Tobe","sequence":"additional","affiliation":[{"name":"Department of Urology Sanjukai Hospital Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Haga","sequence":"additional","affiliation":[{"name":"Department of Urology Sanjukai Hospital Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousuke","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Urology Sanjukai Hospital Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiya","family":"Honma","sequence":"additional","affiliation":[{"name":"Department of Urology Sanjukai Hospital Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/sm2.28","article-title":"An update of the international society of sexual medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE)","volume":"2","author":"Althof SE","year":"2014","journal-title":"J. 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