{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:20:34Z","timestamp":1788272434452,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare transplant outcomes among elderly (aged \u226560\u00a0years) and non\u2010elderly recipients, and to evaluate the acceptability of elderly living donor kidney transplantation in practice after consideration of living donor type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 830 adult patients with <jats:styled-content style=\"fixed-case\">living donor kidney transplantation<\/jats:styled-content> between 2000 and 2011 in this retrospective cohort study. We compared death\u2010censored graft survival, patient survival, biopsy\u2010proven rejection, complications, and renal function in elderly (<jats:italic>n<\/jats:italic>\u00a0=\u00a0119) and non\u2010elderly recipients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0278).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in 10\u2010year death\u2010censored graft survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.980). Corresponding patient survival rates in the elderly and non\u2010elderly groups were 84.1% and 98.1%, respectively (hazard ratio 6.15, 95% confidence interval 2.12\u201317.82, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Elderly patients had more complications and chronic T\u2010cell\u2010mediated rejection. Factors associated with death in elderly recipients with functioning grafts were residual advanced recipient age (<jats:styled-content style=\"fixed-case\">hazard ratio<\/jats:styled-content> 1.39), decreased hemoglobin (<jats:styled-content style=\"fixed-case\">hazard ratio<\/jats:styled-content> 4.10), hepatitis\u00a0B virus (<jats:styled-content style=\"fixed-case\">hazard ratio<\/jats:styled-content> 7.89), hepatitis\u00a0C virus (<jats:styled-content style=\"fixed-case\">hazard ratio<\/jats:styled-content> 13.12) and elevated alanine aminotransferase (<jats:styled-content style=\"fixed-case\">hazard ratio<\/jats:styled-content> 1.13).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elderly <jats:styled-content style=\"fixed-case\">living donor kidney transplantation<\/jats:styled-content> seems to provide adequate acceptable outcomes. However, physicians should be cautious when evaluating elderly patients with hepatitis, and further studies are required to improve long\u2010term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13443","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T01:09:11Z","timestamp":1505437751000},"page":"833-840","source":"Crossref","is-referenced-by-count":17,"title":["Elderly living donor kidney transplantation allows worthwhile outcomes: The Japan Academic Consortium of Kidney Transplantation study"],"prefix":"10.1111","volume":"24","author":[{"given":"Masayoshi","family":"Okumi","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Unagami","sequence":"additional","affiliation":[{"name":"Department of Medicine Kidney Center Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Kakuta","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhiko","family":"Ochi","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Japan Academic Consortium of Kidney Transplantation (JACK)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412303"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04245.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg528"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12579"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00700115"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002650"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13502"},{"issue":"4","key":"e_1_2_8_9_1","first-page":"60","article-title":"European best practice guidelines for renal transplantation. Section\u00a0IV: long\u2010term management of the transplant recipient. IV.13 Analysis of patient and graft survival","volume":"17","author":"Transplantation EEGoR","year":"2002","journal-title":"Nephrol. Dial. Transplant."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12590"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13253"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl637"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.02014.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-6135.2003.00251.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01542.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1681\/ASN.V1341067","article-title":"Matching older kidneys with older patients does not improve allograft survival","volume":"13","author":"Kasiske BL","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000259621.56861.31"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft069"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00864.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07940716"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12971"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1705221"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.10.038"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2016.07.001"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13173"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiju.13443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.13443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T16:19:50Z","timestamp":1696004390000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.13443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,14]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/iju.13443"],"URL":"https:\/\/doi.org\/10.1111\/iju.13443","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,14]]}}}