{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:00:03Z","timestamp":1789117203702,"version":"build-2803163510"},"reference-count":68,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T00:00:00Z","timestamp":1509667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17K11147"],"award-info":[{"award-number":["17K11147"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There has recently been remarkable progress in immunosuppressive agents, such as tacrolimus and cyclosporine. Therefore, the rate of organ establishment has improved in transplantation. However, immunosuppressive agents generally suppress the function of T\u00a0cells. Thus, opportunistic infections, such as cytomegalovirus infection, are still a major problem in kidney transplantation. Induction of specific tolerance to avoid immunosuppressive drug therapy after kidney transplantation is considered as the ultimate goal of transplantation. Various factors induce tolerance that involves establishment of hematopoietic chimerism and various cell subsets. In particular, we have carried out various studies regarding the cyclophosphamide\u2010induced tolerance system. Tolerance is induced after establishment of hematopoietic chimerism after donor bone marrow transplantation. At the clinical stage, kidney transplantation before administration of cyclophosphamide after transfusion of bone marrow to create hematopoietic chimera is considered to be one of the most successful protocols. Furthermore, recent studies have shown the involvement of multiple populations of immune cells in preserving immunological tolerance and promoting long\u2010term renal grafts. The present review focuses on how cyclophosphamide and other immune factors induce tolerance in kidney transplantation.<\/jats:p>","DOI":"10.1111\/iju.13474","type":"journal-article","created":{"date-parts":[[2017,11,4]],"date-time":"2017-11-04T00:06:41Z","timestamp":1509754001000},"page":"112-120","source":"Crossref","is-referenced-by-count":8,"title":["Cyclophosphamide\u2010induced tolerance in kidney transplantation avoids long\u2010term immunosuppressive therapy"],"prefix":"10.1111","volume":"25","author":[{"given":"Ario","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Department of Urology Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Akashi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Eto","sequence":"additional","affiliation":[{"name":"Department of Urology Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.112"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.281"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.146.1.34"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.147.3.700"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199501000-00018"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a015529"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199609270-00026"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.1.97"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198406000-00011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198508000-00016"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.1.213"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.4049\/jimmunol.146.5.1402","article-title":"Specific destruction of host\u2010reactive mature T cells of donor origin prevents graft\u2010versus\u2010host disease in cyclophosphamide\u2010induced tolerant mice","volume":"146","author":"Eto M","year":"1991","journal-title":"J. Immunol."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-016-2106-z"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6471901"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071074"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa074191"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.03992.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003509"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13416"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041399"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2012.10.001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/332035a0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/332040a0"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.6.2005"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.3.779"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2016.07.008"},{"key":"e_1_2_8_28_1","first-page":"113","article-title":"Direct evidence for clonal destruction of allo\u2010reactive T cells in the mice treated with cyclophosphamide after allo\u2010priming","volume":"78","author":"Maeda T","year":"1993","journal-title":"Immunology"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199203000-00022"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.4049\/jimmunol.150.3.753","article-title":"Role of peripheral hemopoietic chimerism in achieving donor\u2010specific tolerance in adult mice","volume":"150","author":"Maeda T","year":"1993","journal-title":"J. Immunol."},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67506-2"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200102150-00019"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26009"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2014.12.001"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009143431101"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1022"},{"key":"e_1_2_8_37_1","first-page":"767","article-title":"Effect of mixed chimerism on graft\u2010versus\u2010host disease, disease recurrence and survival after HLA\u2010identical marrow transplantation for aplastic anemia or chronic myelogenous leukemia","volume":"18","author":"Huss R","year":"1996","journal-title":"Bone Marrow Transplant."},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200102150-00017"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-608406"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006960"},{"key":"e_1_2_8_41_1","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.4049\/jimmunol.157.12.5284","article-title":"Regulatory T cells in maintenance and reversal of peripheral tolerance in\u00a0vivo","volume":"157","author":"Kong YY","year":"1996","journal-title":"J. Immunol."},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-525873"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110767"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00438"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2011.08.009"},{"key":"e_1_2_8_46_1","doi-asserted-by":"crossref","first-page":"e0124927","DOI":"10.1371\/journal.pone.0124927","article-title":"Granzyme A is required for regulatory T\u2010cell mediated prevention of gastrointestinal graft\u2010versus\u2010host disease","volume":"10","author":"Velaga S","year":"2015","journal-title":"PLoS ONE"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0447"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxr120"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-025460"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12194"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0447"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-371948"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.11.3390"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1053\/bbmt.2002.v8.pm12171484"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.03.005"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-344853"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.4081\/pr.2011.s2.e15"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2011.05.001"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.4577"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000064211.23536.AD"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.02.021"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199908270-00006"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31820a3068"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03572.x"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.4.2153"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.01.055"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-291187"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.1.49"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200205150-00005"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiju.13474","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/chorus\/v1\/articles\/10.1111%2Fiju.13474","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.13474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T07:51:09Z","timestamp":1758354669000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.13474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,3]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/iju.13474"],"URL":"https:\/\/doi.org\/10.1111\/iju.13474","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,3]]}}}