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Changes in androgen receptor signaling from androgen deprivation therapy have been linked to therapeutic resistance and tumor progression. Resistant cells can become reprogrammed to undergo epithelial\u2013mesenchymal transition, a phenotypic switch from benign, epithelial cells to a mobile cell with mesenchymal traits. In these cells, attachment to their epithelial cell layer is no longer required for survival. Anoikis is a form of cell death that occurs when detachment from other cells and the basement membrane occurs. Epithelial cells have been shown to undergo epithelial\u2013mesenchymal transition, avoid anoikis induction and progress to a metastatic phenotype. In prostate cancer progression to advanced disease, epithelial\u2013mesenchymal transition induction (characterized by loss of epithelial cellular attachment protein E\u2010cadherin) correlates with a higher Gleason score, tumor progression, increased metastasis and higher biochemical recurrence. The concept of interfacing epithelial\u2013mesenchymal transition with anoikis in the tumor microenvironment landscape will be discussed here, with focus on the significance of the functional exchange between the two processes in therapeutic targeting of advanced disease. The current evidence on the impact of loss of cell\u2013cell contact, acquisition of chemoresistance, immune escape and metastatic spread in advanced tumors in response to transforming growth factor\u2010\u03b2 on prostate cancer metastasis will be also discussed. The signaling cross\u2010talk between transforming growth factor\u2010\u03b2 and androgen receptor signaling will be interrogated as a new therapeutic platform for the development of combination strategies to impair prostate cancer metastasis.<\/jats:p>","DOI":"10.1111\/iju.13505","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T01:32:51Z","timestamp":1516239171000},"page":"318-326","source":"Crossref","is-referenced-by-count":11,"title":["Cell death under epithelial\u2013mesenchymal transition control in prostate cancer therapeutic response"],"prefix":"10.1111","volume":"25","author":[{"given":"Diane","family":"Begemann","sequence":"first","affiliation":[{"name":"Department of Urology University of Kentucky College of Medicine Lexington Kentucky USA"},{"name":"Department of Toxicology and Cancer Biology University of Kentucky College of Medicine Lexington Kentucky 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