{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:32:59Z","timestamp":1763037179919},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the effect of cernitin pollen extract on serum prostate\u2010specific antigen level prostate biopsy candidates, and to develop an ideal protocol to avoid an unnecessary biopsy procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 61 patients were administrated cernitin pollen extract tablets (two tablets t.i.d.) for 30 days, and then underwent a prostate biopsy with \u226512 systematic and targeted biopsy cores obtained. Serum prostate\u2010specific antigen levels were examined before and after administration of the pollen extract, and the change in serum prostate\u2010specific antigen and the rate of change were analyzed in relation to negative and positive biopsy results for cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean change in serum prostate\u2010specific antigen and rate of change after administration of cernitin pollen extract in all patients were \u22120.6 \u00b1 1.4 ng\/mL and \u22127.6 \u00b1 16.1%, respectively, which were significantly different from the baseline values (<jats:italic>P<\/jats:italic> = 0.0003 and <jats:italic>P<\/jats:italic> = 0.0005, respectively). When prostate\u2010specific antigen change values and rates were compared between patients negative and positive for cancer, a significant difference between those groups was observed (<jats:italic>P<\/jats:italic> = 0.04 and <jats:italic>P<\/jats:italic> = 0.03, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study is the first to show that an ideal protocol using cernitin pollen extract has the potential to avoid an unnecessary prostate biopsy procedure in patients with elevated prostate\u2010specific antigen, possibly caused by inflammation. Additional studies with greater numbers of participants are required to confirm our findings and develop an ideal protocol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13549","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T02:56:21Z","timestamp":1522032981000},"page":"479-485","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Oral administration of cernitin pollen extract (Cernilton<sup>\u00ae<\/sup>) for 30 days might be useful to avoid unnecessary biopsy in prostate biopsy candidates: A preliminary study"],"prefix":"10.1111","volume":"25","author":[{"given":"Yoshikazu","family":"Togo","sequence":"first","affiliation":[{"name":"Department of Urology Hyogo College of Medicine Nishinomiya Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daishi","family":"Ichioka","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Urology Showa University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kameyama","sequence":"additional","affiliation":[{"name":"Department of Urology Gifu University Hospital Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Urology Gifu University Hospital Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Hiyama","sequence":"additional","affiliation":[{"name":"Department of Urology Sapporo Medical University School of Medicine Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Infection Control and Laboratory Medicine Sapporo Medical University School of Medicine Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nagae","sequence":"additional","affiliation":[{"name":"Nagae Prostate\u2010care Clinic Hamamatsu Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Hirota","sequence":"additional","affiliation":[{"name":"Department of Pathology Hyogo College of Medicine Nishinomiya Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo College of Medicine Nishinomiya Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Japanese Research Group for Urinary Tract Infection (JRGU)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.16.2.95"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810084"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.05.049"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000052500"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000162017.24965.2b"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.pcan.4500996"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000112612"},{"key":"e_1_2_8_9_1","unstructured":"EngelerD BaranowskiAP BorovickaJet al. 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