{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:51:23Z","timestamp":1760014283706},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the efficacy of silodosin as second\u2010line \u03b1\u2010blocker monotherapy in patients with lower urinary tract symptoms as a result of benign prostatic hyperplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Men who were given an \u03b1\u2010blocker other than silodosin for \u22658 weeks, aged \u226550 years, had a total International Prostate Symptom Score \u226513 and quality of life index \u22654 were enrolled. After treatment with 8 mg\/day silodosin for 8 weeks, symptoms and treatment satisfaction were assessed. If the patients still complained and hoped for readministration of the first\u2010line \u03b1\u2010blocker, the previous medication was administered again for 8 weeks in the case of persisting symptoms, and efficacy was again evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 73 patients were enrolled and analyzed at 8 weeks. Silodosin administration significantly improved the International Prostate Symptom Score and Overactive Bladder Symptom Score. The quality of life index was improved by at least 1 point in 49.3% patients, and its mean change was significantly greater in the group with previous naftopidil treatment than in those with tamsulosin. A total of 59 patients hoped to continue silodosin, and 13 requested administration of the first\u2010line \u03b1\u2010blocker. Previously taking naftopidil and having a shorter duration of prior \u03b1\u2010blocker treatment at baseline were associated with silodosin continuation. Although prior \u03b1\u2010blocker readministration in the 13 patients did not show significant efficacy, six preferred to continue the previous \u03b1\u2010blocker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Silodosin represents an effective second\u2010line \u03b1\u2010blocker monotherapy, even in those who still have moderate lower urinary tract symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13757","type":"journal-article","created":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T05:32:19Z","timestamp":1533187939000},"page":"849-854","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Silodosin as second\u2010line \u03b1\u2010blocker monotherapy in patients with benign prostatic hyperplasia: A prospective observational study"],"prefix":"10.1111","volume":"25","author":[{"given":"Koji","family":"Ichihara","sequence":"first","affiliation":[{"name":"Department of Urology Sapporo Medical University School of Medicine Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Masumori","sequence":"additional","affiliation":[{"name":"Department of Urology Sapporo Medical University School of Medicine Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Iwasawa","sequence":"additional","affiliation":[{"name":"Iwasawa Clinic Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Urology Oji General Hospital Tomakomai Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Asahikawa Urological Clinic Asahikawa Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Motomachi Urological Clinic Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Sasamura","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido Medical Center Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobukazu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Teine Urological Clinic Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Haga","sequence":"additional","affiliation":[{"name":"Department of Urology Sanjyukai Hospital Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriomi","family":"Miyao","sequence":"additional","affiliation":[{"name":"Department of Urology Muroran City General Hospital Muroran Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaoki","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Urology JCHO Hokkaido Hospital Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13401"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-012-0944-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-12-29"},{"key":"e_1_2_8_5_1","first-page":"13","article-title":"Investigation of adverse events and the continuance rate of silodosin in all patients who received silodosin for lower urinary tract symptoms suggestive of benign prostatic hyperplasia","volume":"101","author":"Furuya R","year":"2010","journal-title":"Nihon Hinyoukika Gakkai 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