{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T17:30:17Z","timestamp":1770831017630,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T00:00:00Z","timestamp":1534118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To elucidate the effects of the preoperative albumin\u00a0:\u00a0globulin ratio on the survival of patients with upper tract urothelial carcinoma after radical nephroureterectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed 124 consecutive patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy at Chiba Cancer Center, Chiba, Japan between 2002 and 2015. The albumin\u00a0:\u00a0globulin ratio was defined: albumin\u00a0\/\u00a0(total protein\u00a0\u2212\u00a0albumin). Associations between preoperative clinicopathological factors, including the albumin\u00a0:\u00a0globulin ratio, and recurrence\u2010free survival, cancer\u2010specific survival and overall survival were assessed. The log\u2013rank test and Cox proportional hazards models were used for univariate and multivariable analyses, respectively. The study cohort was separated into two groups based on the optimal albumin\u00a0:\u00a0globulin ratio cut\u2010off value determined using receiver operating characteristic curve analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median survival time was 55\u00a0months (interquartile range 28\u201376\u00a0months), and 31 patients died during follow up. A low preoperative albumin\u00a0:\u00a0globulin ratio &lt;1.40 was associated with tumor grade and surgical margin status. Kaplan\u2013Meier analyses showed that a low albumin\u00a0:\u00a0globulin ratio was more significantly correlated with worse recurrence\u2010free survival, cancer\u2010specific survival and overall survival. Multivariate analyses showed that a low albumin\u00a0:\u00a0globulin ratio was an independent predictive factor associated with poor recurrence\u2010free survival (hazard ratio 3.758; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0028), cancer\u2010specific survival (hazard ratio 5.687; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0044) and overall survival (hazard ratio 3.124; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0030).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A low albumin\u00a0:\u00a0globulin ratio is an independent predictive factor associated with poor prognosis in upper tract urothelial carcinoma patients treated with radical nephroureterectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13767","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T23:39:38Z","timestamp":1534203578000},"page":"871-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prognostic role of the preoperative serum albumin\u00a0:\u00a0globulin ratio after radical nephroureterectomy for upper tract urothelial carcinoma"],"prefix":"10.1111","volume":"25","author":[{"given":"Masafumi","family":"Otsuka","sequence":"first","affiliation":[{"name":"Prostate Center and Division of Urology Chiba Cancer Center Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Kamasako","sequence":"additional","affiliation":[{"name":"Prostate Center and Division of Urology Chiba Cancer Center Chiba 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