{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T21:20:23Z","timestamp":1780608023745,"version":"3.54.1"},"reference-count":139,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:00:00Z","timestamp":1540771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["(MOST107\u20102314\u2010B\u2010182A\u2010018\u2010MY3)"],"award-info":[{"award-number":["(MOST107\u20102314\u2010B\u2010182A\u2010018\u2010MY3)"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["(CMRPG3F0221)"],"award-info":[{"award-number":["(CMRPG3F0221)"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Urothelial carcinoma in the upper tract is rare and often discussed separately. Many established risk factors were identified for the disease, including genetic and external risk factors. Radiographic survey, endoscopic examination and urine cytology remained the most important diagnostic modalities. In localized upper tract urothelial carcinomas, radical nephroureterectomy with bladder cuff excision are the gold standard for large, high\u2010grade and suspected invasive tumors of the renal pelvis and proximal ureter, whereas kidney\u2010sparing surgeries should be considered in patients with low\u2010risk disease. Advances in technology have given endoscopic surgery an important role, not only in diagnosis, but also in treatment. Although platinum\u2010based combination chemotherapy is efficacious in advanced or metastatic disease, current established chemotherapy regimens are toxic and lack a sustained response. Immune checkpoint inhibitors have led to a new era of treatment for advanced or metastatic urothelial carcinomas. The remarkable results achieved thus far show that immunotherapy will likely be the future treatment paradigm. The combination of immune checkpoint inhibitors and other agents is another inspiring avenue to explore that could benefit even more patients. With respect to the high incidence rate and different clinical appearance of upper tract urothelial carcinomas in Taiwan, a possible correlation exists between exposure to certain external risk factors, such as arsenic in drinking water and aristolochic acid in Chinese herbal medicine. As more gene sequencing differences between upper tract urothelial carcinomas and various disease causes are detailed, this has warranted the era of individualized screening and treatment for the disease.<\/jats:p>","DOI":"10.1111\/iju.13826","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T23:38:50Z","timestamp":1540856330000},"page":"148-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Recent advances in upper tract urothelial carcinomas: From bench to clinics"],"prefix":"10.1111","volume":"26","author":[{"given":"I\u2010Hung","family":"Shao","sequence":"first","affiliation":[{"name":"Division of Urology Department of Surgery Linkou Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Hsu","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery Linkou Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"See\u2010Tong","family":"Pang","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery Linkou Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.06.044"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.12.042"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24147"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08838.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.50.1.7"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11298.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.09.048"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.07.042"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-010-0594-7"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24135"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0094-0143(21)00491-2","article-title":"Pathology and staging of urothelial tumors of the kidney and ureter","volume":"20","author":"Melamed MR","year":"1993","journal-title":"Urol. Clin. North Am."},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.01.030"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000273466"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32143"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(00)00426-X"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)39853-1"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2010.076992"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.07.047"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.237"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00561-4"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006086"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.349"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12912"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.04.038"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1625"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aai8312"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2011.92"},{"key":"e_1_2_12_30_1","first-page":"1091","article-title":"Prognostic value of p53 protein overexpression in upper tract urothelial carcinomas in Taiwan","volume":"33","author":"Lee YC","year":"2013","journal-title":"Anticancer Res."},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.05.048"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.06.050"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.06.013"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.07.039"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.4137\/BMI.S6487"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3929"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12661"},{"key":"e_1_2_12_38_1","first-page":"254","article-title":"Cigarette smoking and cancers of the renal pelvis and ureter","volume":"52","author":"McLaughlin JK","year":"1992","journal-title":"Can. Res."},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197403)33:3<743::AID-CNCR2820330321>3.0.CO;2-M"},{"key":"e_1_2_12_40_1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0094-0143(21)00763-1","article-title":"Advances in the etiology of urothelial cancer","volume":"11","author":"Morrison AS","year":"1984","journal-title":"Urol. Clin. North Am."},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1986.154"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01529-7"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07565.x"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2017.03.008"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92984-2"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/11.7.1359"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.3.524"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.06793.x"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp467"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.371"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006083422301"},{"key":"e_1_2_12_52_1","first-page":"2025","article-title":"Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy","volume":"56","author":"Schmeiser HH","year":"1996","journal-title":"Can. Res."},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2006.02.017"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308607101"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701248104"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26077"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28013"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910410414"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38730-X"},{"key":"e_1_2_12_60_1","first-page":"2327","volume-title":"Campbell's Urology","author":"Messing EM","year":"1998"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-012-0877-2"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)55935-2"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)54881-8"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11691"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65570-8"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(96)00571-7"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.1.94"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)55269-6"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19881101)62:9<2016::AID-CNCR2820620924>3.0.CO;2-G"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)00563-4"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2000.00344.x"},{"key":"e_1_2_12_72_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0094-0143(21)01097-1","article-title":"Upper urinary tract urothelial tumors","volume":"3","author":"Batata M","year":"1976","journal-title":"Urol. Clin. North Am."},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.05.158"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197506)35:6<1626::AID-CNCR2820350623>3.0.CO;2-C"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06524.x"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2222010667"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00800-1"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)44875-0"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)41286-9"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67970-0"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.03.051"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000000373"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-200102000-00081"},{"key":"e_1_2_12_84_1","first-page":"8620","article-title":"Fluorescence in\u00a0situ hybridization (FISH) in the diagnosis of bladder and upper tract urothelial carcinoma: the largest single\u2010institution experience to date","volume":"24","author":"Gomella LG","year":"2017","journal-title":"Can. J. Urol."},{"key":"e_1_2_12_85_1","doi-asserted-by":"crossref","first-page":"26106","DOI":"10.18632\/oncotarget.15344","article-title":"Fluorescence in\u00a0situ hybridization status of voided urine predicts invasive and high\u2010grade upper tract urothelial carcinoma","volume":"8","author":"Su X","year":"2017","journal-title":"Oncotarget"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.09072.x"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-011-0677-0"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.02.030"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.06.029"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12400"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1015-9584(08)60050-0"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2011.0426"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10792.x"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.05.049"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.09.017"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2011.12.004"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.07.035"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.03.030"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.12.035"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2008.10.023"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.2144"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22970"},{"key":"e_1_2_12_103_1","unstructured":"Bob PhillipsCB SackettD BadenochD StrausS HaynesB DawesM.Oxford Centre for evidence\u2010based medicine levels of evidence(May 2009). Updated by Jeremy Howick March2009."},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.08003.x"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2010.07.010"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.11.035"},{"issue":"3","key":"e_1_2_12_107_1","first-page":"703","article-title":"Advanced transitional cell carcinoma of the upper urinary tract: patterns of failure, survival and impact of postoperative adjuvant radiotherapy","volume":"160","author":"Hall MC","year":"1998","journal-title":"J. Urol."},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07988.x"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.09.010"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2015.553"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08821.x"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.12.075"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9056(18)32045-1"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.03.077"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.07.036"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.07.014"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.06.016"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.10960.x"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2017.12.009"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11446"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.01.006"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07535.x"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.11.018"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.02.005"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11068.x"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2017.0915"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.03.003"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.69.4141"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2017.12.007"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13904"},{"key":"e_1_2_12_131_1","unstructured":"HussainS Syed HussainTP LoriotYet\u00a0al.IMvigor211: A global open\u2010label phase III randomised study examining atezolizumab vs chemotherapy for platinum\u2010treated advanced urothelial carcinoma.2017: Abstracts from the NCRI Cancer Conferences."},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30007-4"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613683"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30496-X"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30065-7"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-15-0059"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw373.05"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.34.15_suppl.4514"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.9761"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-0569"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiju.13826","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.13826","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iju.13826","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.13826","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T03:30:45Z","timestamp":1694662245000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.13826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,29]]},"references-count":139,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/iju.13826"],"URL":"https:\/\/doi.org\/10.1111\/iju.13826","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,29]]},"assertion":[{"value":"2018-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}