{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:35:01Z","timestamp":1780756501136,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T00:00:00Z","timestamp":1542758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the detection rates of clinically significant prostate cancer classified according to the prostate imaging reporting and data system scoring system using magnetic resonance imaging\/ultrasound rigid fusion targeted biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 339 patients underwent transperineal magnetic resonance imaging\/ultrasound rigid fusion targeted biopsy in our institution between January 2015 and July 2017. Patients with prostate imaging reporting and data system category\u00a01 or 2 and those with a pre\u2010biopsy prostate\u2010specific antigen value of &gt;30\u00a0ng\/mL were excluded from this study. Finally, 310 patients were recruited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The detection rates of clinically significant prostate cancer with prostate imaging reporting and data system category\u00a03, 4, and 5 were 1.0% (1\/98), 35.1% (47\/134) and 73.1% (57\/78), respectively. The factors affecting the detection of clinically significant prostate cancer with prostate imaging reporting and data system categories\u00a04 and 5 were: (i) prostate imaging reporting and data system category\u00a05; (ii) prostate volume &lt;40\u00a0cc; (iii) no previous biopsy; (iv) lesion located in the peripheral zone; and (v) prostate\u2010specific antigen density &gt;0.35\u00a0ng\/mL\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The detection rate of clinically significant prostate cancer on magnetic resonance imaging\/ultrasound rigid fusion targeted biopsy is very low in patients with prostate imaging reporting and data system category\u00a03; therefore, patients with this classification should not undergo targeted biopsy. Prostate\u2010specific antigen density, prostate volume, locations of suspected cancer and history of biopsy should be considered to predict the detection rate of clinically significant prostate cancer with prostate imaging reporting and data system categories\u00a04 and 5.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13842","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T10:22:09Z","timestamp":1542795729000},"page":"217-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Detection rate of clinically significant prostate cancer in magnetic resonance imaging and ultrasonography\u2010fusion transperineal targeted biopsy for lesions with a prostate imaging reporting and data system version\u00a02 score of 3\u20135"],"prefix":"10.1111","volume":"26","author":[{"given":"Yuji","family":"Hakozaki","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Metropolitan 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