{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:21:34Z","timestamp":1776921694854,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate kidney function change during adrenalectomy in patients with primary aldosteronism and assess predictors of kidney function decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study included 90 patients who underwent adrenalectomy for primary aldosteronism between 2004 and 2017. Kidney function was evaluated 1\u00a0month after surgery. Predictors associated with a \u226510% decline in the estimated glomerular filtration rate were investigated. Kidney parenchymal volume was compared before and after surgery in 10 patients using volumetric studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean estimated glomerular filtration rate decline in the total cohort at 1\u00a0month after surgery was 13.3% (before: 72.9\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>, after: 64.9\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). The mean serum plasma aldosterone concentration (before: 373\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL <\/jats:styled-content><jats:italic>vs<\/jats:italic> after: 78\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>,<jats:italic> P<\/jats:italic>\u00a0&lt;\u00a00.0001) and potassium level (before: 3.7\u00a0<jats:styled-content style=\"fixed-case\">mE<\/jats:styled-content>q\/L <jats:italic>vs<\/jats:italic> after: 3.9\u00a0<jats:styled-content style=\"fixed-case\">mE<\/jats:styled-content>q\/L, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001) were also significantly different after surgery. Age (odds ratio 6.37, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0006), preoperative plasma aldosterone concentration (odds ratio 3.12, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0209) and preoperative serum potassium level (odds ratio 2.87, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0010) were independent predictors of a \u226510% decline in estimated glomerular filtration rate. Volumetric studies in 10 patients showed that mean postoperative parenchymal volume was significantly decreased compared with the preoperative volume (263\u00a0cc <jats:italic>vs<\/jats:italic> 312\u00a0cc, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0003), with decreases in estimated glomerular filtration rate from 63 to 56\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0146).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Kidney function deterioration after adrenalectomy can be detected in patients with primary aldosteronism. Age, preoperative plasma aldosterone concentration and preoperative potassium level are significant predictors of a decrease in the estimated glomerular filtration rate. Normal parenchymal volume decreases in line with renal functional deterioration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13844","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T23:54:51Z","timestamp":1541116491000},"page":"229-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Assessment of postoperative renal function after adrenalectomy in patients with primary aldosteronism"],"prefix":"10.1111","volume":"26","author":[{"given":"Tadashi","family":"Onohara","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junpei","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Okumi","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsunenori","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Medical Center East Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0104"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60834-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ11-0133"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.KR-105"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.193"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1994.tb02519.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(00)80019-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.22.2638"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12029"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2005.02.010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04415.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118867"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00701.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003930"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2180"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.krcp.2016.05.002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2245"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90490-9"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.07.057"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1851"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000230444.01215.6a"},{"key":"e_1_2_7_25_1","first-page":"271","article-title":"Morphologic aspects of low\u2010potassium and low\u2010sodium nephropathy","volume":"19","author":"Riemenschneider T","year":"1983","journal-title":"Clin. 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