{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T02:07:12Z","timestamp":1771294032085,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,27]],"date-time":"2018-10-27T00:00:00Z","timestamp":1540598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate postoperative residual renal function after radical nephroureterectomy for upper tract urothelial carcinoma using the preoperative dynamic computed tomography renal cortex enhancement ratio in comparison with the split kidney glomerular filtration rate measured by <jats:sup>99m<\/jats:sup>Tc\u2010diethylenetriaminopentacetic acid renography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 47 patients who received radical nephroureterectomy and underwent both preoperative dynamic computed tomography and renography were the model\u2010development cohort; and 109 patients who underwent dynamic computed tomography alone were the validation cohort. Postoperative renal function of the unremoved kidney was estimated using the following formulas: preoperative estimated glomerular filtration rate \u00d7 the percentage of total renal cortex radiodensity for the intact kidney in Hounsfield units obtained from corticomedullary phase images in the computed tomography\u2010based model, or the percentage of the total glomerular filtration rate measured by renography in the nuclear model. The correlation between observed and estimated postoperative renal function was determined. The computed tomography\u2010based prediction model derived from linear regression analysis was validated externally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The correlation of computed tomography\u2010based split renal function with the observed postoperative estimated glomerular filtration rate (<jats:italic>r<\/jats:italic> = 0.80) was equivalent to that of nuclear split renal function (<jats:italic>r<\/jats:italic> = 0.78). In the validation cohort, the computed tomography\u2010based prediction model showed an equivalently strong correlation (<jats:italic>r<\/jats:italic> = 0.78).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study showed that the percentage of total renal cortex radiodensity for the intact kidney is a useful tool for predicting unremoved kidney function in upper tract urothelial carcinoma patients, thereby allowing appropriate patient selection for perioperative cisplatin\u2010based combination chemotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13855","type":"journal-article","created":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T01:37:33Z","timestamp":1540690653000},"page":"266-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictive ability of renal cortex enhancement in dynamic computed tomography for residual renal function after nephroureterectomy: Comparison with <sup>99m<\/sup>Tc\u2010diethylenetriaminopentacetic acid renography and validation study"],"prefix":"10.1111","volume":"26","author":[{"given":"Yuma","family":"Waseda","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yudai","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Urology Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keizo","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Urology Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minato","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichiro","family":"Ishioka","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoh","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Urology Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Kihara","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,27]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1301","article-title":"Procedures of choice in renal nuclear medicine","volume":"32","author":"Blaufox MD","year":"1991","journal-title":"J. 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