{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T06:16:30Z","timestamp":1776579390884,"version":"3.51.2"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the incidence and preoperative risk factors of post\u2010excisional hypoglycemia in patients undergoing pheochromocytoma resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent surgical resection of pheochromocytoma at a single institution were retrospectively enrolled in the present study. The primary end\u2010point was the development of post\u2010excisional hypoglycemia; that is, a serum glucose level &lt;70\u00a0mg\/dL. The serum levels of immunoreactive insulin and glucose levels during the preoperative oral glucose\u2010tolerance test and surgery were analyzed to elucidate the mechanism of hypoglycemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 49 patients underwent surgical resection of pheochromocytoma, of which 21 patients (43%) developed post\u2010excisional hypoglycemia. The incidence of hypoglycemia was not statistically different between patients with adrenal tumors and those with extra\u2010adrenal tumors (18\/41 [44%] <jats:italic>vs<\/jats:italic> 3\/8 [38%], respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.73). There was no difference in the immunoreactive insulin\/glucose ratio during the preoperative oral glucose\u2010tolerance test between patients with and those without post\u2010excisional hypoglycemia. The intraoperative immunoreactive insulin\/glucose ratio was significantly higher in patients with hypoglycemia than in those without hypoglycemia. A higher 24\u2010h urinary epinephrine level, but not norepinephrine level, was a predictive factor for post\u2010excisional hypoglycemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Post\u2010excisional hypoglycemia is a frequent complication of pheochromocytoma resection, irrespective of the tumor location, and might be common in patients with epinephrine\u2010predominant tumors. All patients undergoing resection of adrenal and extra\u2010adrenal pheochromocytoma require intensive monitoring of serum glucose levels during and after surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13864","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T05:54:49Z","timestamp":1542952489000},"page":"273-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Incidence and predictive factors of hypoglycemia after pheochromocytoma resection"],"prefix":"10.1111","volume":"26","author":[{"given":"Saori","family":"Araki","sequence":"first","affiliation":[{"name":"Department of Urology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Kijima","sequence":"additional","affiliation":[{"name":"Department of Urology Graduate School of Medical and Dental 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