{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T06:36:39Z","timestamp":1787207799244,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the incidence of penile intraepithelial neoplasia in the Netherlands using a nationwide histopathology registry and to discuss the nomenclature of premalignant penile lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from patients in the Netherlands diagnosed with a premalignant penile lesion between January 1998 and December 2007 were collected from the nationwide histopathology registry <jats:styled-content style=\"fixed-case\">(PALGA)<\/jats:styled-content>; this database covers all pathology reports of inhabitants in the Netherlands. The premalignant lesions included were erythroplasia of Queyrat; Bowen's disease; bowenoid papulosis; mild, moderate and severe dysplasia; and carcinoma <jats:italic>in situ<\/jats:italic> of the penis. The terminology used in the pathological reports was translated to penile intraepithelial neoplasia. The grading was made analogous to that of vulvar premalignant lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">PALGA<\/jats:styled-content> database enrolled 380 patients with premalignant penile lesions. Severe premalignant lesions, penile intraepithelial neoplasia <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, were found in 254 patients (67%), penile intraepithelial neoplasia <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> in 84 (22%) and penile intraepithelial neoplasia I in 42 patients (11%). Most lesions were located on the prepuce (45%), followed by glans (38%) and shaft (3%). The median age of patients with penile intraepithelial neoplasia was 58 years. Progression to malignant disease occurred (2% for penile intraepithelial neoplasia I <jats:italic>vs<\/jats:italic> 7% for penile intraepithelial neoplasia <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>) in 26 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Penile intraepithelial neoplasia is a rarely diagnosed condition. Because of the wide variation of terms used for premalignant intraepithelial neoplasia of the penis, we recommend restricting this nomenclature to penile intraepithelial neoplasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13871","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T23:58:52Z","timestamp":1543881532000},"page":"353-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Penile intraepithelial neoplasia: Nomenclature, incidence and progression to malignancy in the Netherlands"],"prefix":"10.1111","volume":"26","author":[{"given":"Robert J","family":"Hoekstra","sequence":"first","affiliation":[{"name":"Department of Urology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien J","family":"Trip","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology St Antonius Hospital Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fybo JW","family":"ten Kate","sequence":"additional","affiliation":[{"name":"Department of Pathology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Horenblas","sequence":"additional","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute\u2010Antoni van Leeuwenhoek Hospital Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MTW Tycho","family":"Lock","sequence":"additional","affiliation":[{"name":"Department of Urology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-003-0181-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00069.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-008-0302-z"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25355"},{"key":"e_1_2_10_6_1","first-page":"45","article-title":"Cancer incidence in five continents. 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