{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:34:21Z","timestamp":1789655661727,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T00:00:00Z","timestamp":1545782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether switching ciprofloxacin to fosfomycin in the case of fluoroquinolone\u2010resistant rectal bacteria influences the incidence of infectious complications after transrectal prostate biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From December 2015 until December 2017, patients undergoing prostate biopsy were randomly assigned to a control group or an intervention group in a prospective, open\u2010label fashion at three different centers. The presence of fluoroquinolone\u2010resistant organisms was detected by rectal swabs. Patients in the control group received ciprofloxacin. Patients in the intervention group received fosfomycin instead of ciprofloxacin in the case of fluoroquinolone\u2010resistant bacteria on rectal swab culture. The primary end\u2010point was the difference in occurrence of major (febrile) and minor (afebrile) infections between both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 102 patients were randomized to the control group, and 102 patients to the intervention group. In the control group, nine complications occurred, of which five were major febrile complications. In the intervention group, six complications occurred, of which four were major febrile complications. The total number of complications (major and minor) did not differ between both groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.59). A subgroup analysis of patients with fluoroquinolone\u2010resistant bacteria on rectal swab showed five complications in the control group and one complication in the intervention group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.09).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This represents the first prospective randomized study using rectal cultures for targeted antibiotic prophylaxis. Study findings show promising results for use of fosfomycin in patients with fluoroquinolone resistance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13883","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T06:58:45Z","timestamp":1545893925000},"page":"391-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Use of fosfomycin as targeted antibiotic prophylaxis before prostate biopsy: A prospective randomized study"],"prefix":"10.1111","volume":"26","author":[{"given":"Jeroen","family":"Van Besien","sequence":"first","affiliation":[{"name":"Department of Urology AZ Sint\u2010Lucas Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Uvin","sequence":"additional","affiliation":[{"name":"Department of Urology AZ Sint\u2010Lucas Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Weyne","sequence":"additional","affiliation":[{"name":"Department of Urology AZ Sint\u2010Lucas Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Van Praet","sequence":"additional","affiliation":[{"name":"Department of Urology AZ Sint\u2010Lucas Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Merckx","sequence":"additional","affiliation":[{"name":"Department of Urology AZ Sint\u2010Lucas Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"De Graeve","sequence":"additional","affiliation":[{"name":"Department of Urology AZ Sint\u2010Lucas Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koenraad","family":"Van Renterghem","sequence":"additional","affiliation":[{"name":"Department of Urology Jessa Hospital Hasselt Belgium"},{"name":"Department of Urology Sint Franciscus Hospital Heusden\u2010Zolder Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinoud","family":"Cartuyvels","sequence":"additional","affiliation":[{"name":"Department of Microbiology Jessa Hospital Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Van den Abeele","sequence":"additional","affiliation":[{"name":"Department of Microbiology AZ Sint\u2010Lucas Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.08.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2011.130"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.05.049"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.11.043"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.04.044"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.07.1392"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1434"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.09.057"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.11.115"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/671734"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.09.035"},{"key":"e_1_2_8_13_1","unstructured":"The European Committee on Antimicrobial Susceptibility Testing.Breakpoint tables for interpretation of MICs and zone diameters. 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