{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:27:15Z","timestamp":1787678835228,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:00:00Z","timestamp":1545004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the long\u2010term efficacy and safety of periurethral injection of autologous adipose\u2010derived regenerative cells for the treatment of post\u2010prostatectomy stress urinary incontinence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 13 patients with persistent stress urinary incontinence after prostate surgery (radical prostatectomy, 10 patients; holmium laser enucleation of the prostate, three patients) underwent periurethral injection of adipose\u2010derived regenerative cells and were followed up for &gt;4\u00a0years. A 24\u2010h pad test was carried out for four consecutive days in each evaluation period, and changes in the mean daily leakage volume during the 4\u00a0days from baseline to 60\u00a0months after treatment were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean follow\u2010up period was 69\u00a0months (range 55\u201372\u00a0months). The mean leakage volume\/24\u00a0h in all patients changed from 260.7\u00a0g to 152.7\u00a0g. Urinary incontinence progressively improved up to 12\u00a0months after treatment in 10 patients, who maintained improvement up to the final assessment, with the mean daily leakage volume decreasing from 281.5\u00a0g to 119.0\u00a0g (reduction rate 57.7%). The other three patients showed no improvement at 1\u00a0year and at the final assessment. After the perioperative period, significant adverse events or prostate\u2010specific antigen increase were not observed during long\u2010term follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present findings suggest that periurethral injection of autologous adipose\u2010derived regenerative cells is a safe and feasible treatment modality with long\u2010term efficacy for patients with male stress urinary incontinence caused by urethral sphincter deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13886","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:11:23Z","timestamp":1545091883000},"page":"400-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Treatment of male stress urinary incontinence using autologous adipose\u2010derived regenerative cells: Long\u2010term efficacy and safety"],"prefix":"10.1111","volume":"26","author":[{"given":"Momokazu","family":"Gotoh","sequence":"first","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tokunori","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Center for Advanced Medicine and Clinical Research Nagoya University Hospital Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Matsukawa","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Majima","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Takai","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Funahashi","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Toriyama","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,17]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"266","article-title":"Epidemiologic survey on lower urinary tracts symptoms in Japan","volume":"14","author":"Homma Y","year":"2003","journal-title":"J. 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