{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:07:27Z","timestamp":1773317247769,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To identify oncogenes regulated by micro\n                      <jats:styled-content style=\"fixed-case\">\u2010ribonucleic acid<\/jats:styled-content>\n                      ,\n                      <jats:italic>miR\u2010199a\/b\u20103p<\/jats:italic>\n                      , in metastatic castration\u2010resistant prostate cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Advanced ribonucleic acid sequencing technologies were applied to construct a micro\u2010ribonucleic acid expression signature using metastatic castration\u2010resistant prostate cancer autopsy specimens. Ectopic expression of mature micro\u2010ribonucleic acids or small\u2010interfering ribonucleic acids were applied to functional assays for cancer cell lines. Genome\u2010wide gene expression and\n                      <jats:italic>in\u00a0silico<\/jats:italic>\n                      database analyses were carried out to predict micro\u2010ribonucleic acid targets.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ectopic expression of\n                      <jats:italic>miR\u2010199a\/b<\/jats:italic>\n                      inhibited cancer cell aggressiveness. The gene coding for non\u2010structural maintenance of chromosomes condensin\u00a0I complex subunit\u00a0H was directly regulated by\n                      <jats:italic>miR\u2010199a\/b\u20103p<\/jats:italic>\n                      . High expression of condensin\u00a0I complex subunit\u00a0H was significantly associated with poor disease\u2010free survival by The Cancer Genome Atlas database analysis (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.0001). Overexpression of condensin\u00a0I complex subunit\u00a0H was detected in hormone\u2010sensitive prostate cancer and castration\u2010resistant prostate cancer specimens, and knockdown assays showed that its expression enhanced cancer cell migration and invasive abilities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Small ribonucleic acid sequencing of metastatic castration\u2010resistant prostate cancer specimens showed the presence of several antitumor micro\u2010ribonucleic acids whose targets are involved in hormone\u2010sensitive prostate cancer and metastatic castration\u2010resistant prostate cancer pathogenesis. Condensin\u00a0I complex subunit\u00a0H seems to be a promising diagnostic marker and therapeutic target for this disease. Our approach, based on the roles of anti\u2010tumor micro\u2010ribonucleic acids and their targets, will contribute to an improved understanding of the molecular pathogenesis of hormone\u2010sensitive prostate cancer and metastatic castration\u2010resistant prostate cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.13911","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T19:17:37Z","timestamp":1551381457000},"page":"506-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Micro\n                    <scp>\u2010ribonucleic acid<\/scp>\n                    expression signature of metastatic castration\u2010resistant prostate cancer: Regulation of\n                    <i>\n                      <scp>NCAPH<\/scp>\n                    <\/i>\n                    by antitumor\n                    <i>miR\u2010199a\/b\u20103p<\/i>"],"prefix":"10.1111","volume":"26","author":[{"given":"Takayuki","family":"Arai","sequence":"first","affiliation":[{"name":"Department of Functional Genomics Chiba University Graduate School of Medicine Chiba Japan"},{"name":"Department of Urology Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Urology Teikyo University Chiba Medical Center Ichihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaka","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Functional Genomics Chiba University Graduate School of Medicine Chiba Japan"},{"name":"Department of Urology Chiba University Graduate School of Medicine Chiba 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