{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:53:25Z","timestamp":1787237605977,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:00:00Z","timestamp":1551052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H05467"],"award-info":[{"award-number":["16H05467"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the preventive effect of an insulin\u2010like growth factor\u00a01 sustained\u2010release collagen urethral catheter on urethral stricture after urethral injury in a rabbit model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We made urethral catheters coated either with insulin\u2010like growth factor 1\u00a0impregnated collagen or with only collagen, and we divided 19 male Japanese white rabbits into three groups according to the kind of catheter inserted immediately after the rabbit's urethra was injured by electrocoagulation. Group\u00a01 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a07) had a catheter coated with insulin\u2010like growth factor 1 impregnated collagen inserted; group\u00a02 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a07) had a catheter coated with only collagen inserted; and group\u00a03 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a05) had an uncoated catheter inserted. A total of 14 days later, the injured urethras were evaluated by urethrography and urethroscopy, and were also histologically examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Urethrography showed that the ratio of the urethral lumen diameter in injured urethra to that in normal urethra was the largest in group\u00a01 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). In addition, five of the seven rabbits in group\u00a01 (71.4%) had a urethral lumen large enough for passage of a urethroscope, a fraction larger than the corresponding fractions in groups\u00a02 (57.1%) and 3 (20%). On histological analysis, the injured area not covered with regenerated urethral epithelium tended to be smaller in group\u00a01 than the other two groups, but the mean difference was not significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.19).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An insulin\u2010like growth factor\u00a01 sustained\u2010release collagen urethral catheter significantly improves wound healing and prevents urethral stricture after urethral injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.13931","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T02:08:00Z","timestamp":1551146880000},"page":"572-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Insulin\u2010like growth factor\u00a01 sustained\u2010release collagen on urethral catheter prevents stricture after urethral injury in a rabbit model"],"prefix":"10.1111","volume":"26","author":[{"given":"Masayuki","family":"Shinchi","sequence":"first","affiliation":[{"name":"Department of Urology National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Kushibiki","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering National Defense Medical College Tokorozawa Saitama 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