{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:42:55Z","timestamp":1770752575652,"version":"3.50.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002973","name":"Daiichi Sankyo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate a regimen of targeted prophylaxis using rectal swab culture in patients undergoing transrectal ultrasound\u2010guided prostate biopsy, and to investigate the characteristics of isolated fluoroquinolone\u2010resistant <jats:italic>Escherichia coli<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was carried out from June 2013 through December 2014. Rectal swabs were cultured on agar plates containing either 2\u00a0\u03bcg\/mL levofloxacin or 1\u00a0\u03bcg\/mL sitafloxacin before transrectal ultrasound\u2010guided prostate biopsy. Patients with susceptible organisms received levofloxacin or sitafloxacin, whereas those with resistant organisms received directed antimicrobial prophylaxis according to the results of the antimicrobial susceptibility test. Patients with infectious complications after prostate biopsy were identified, and characteristics of patients carrying fluoroquinolone\u2010resistant <jats:italic>Escherichia coli<\/jats:italic> were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 397 men underwent transrectal ultrasound\u2010guided prostate biopsy. Of these patients, 74 (18.6%) had fluoroquinolone\u2010resistant <jats:italic>Escherichia coli<\/jats:italic>. All fluoroquinolone\u2010resistant <jats:italic>Escherichia coli<\/jats:italic> were susceptible to amikacin and meropenem. The risk factor for possible fluoroquinolone\u2010resistant <jats:italic>Escherichia coli<\/jats:italic> was age of \u226573\u00a0years. Three (0.7%) patients who received appropriate antimicrobial prophylaxis had high\u2010grade fever after the prostate biopsy. However, the pathogens were not fluoroquinolone\u2010resistant <jats:italic>Escherichia coli<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Targeted antimicrobial prophylaxis in patients undergoing transrectal ultrasound\u2010guided prostate biopsy can be associated with reducing severe infectious complications caused by fluoroquinolone\u2010resistant <jats:italic>Escherichia coli<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13960","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T23:50:37Z","timestamp":1554767437000},"page":"655-660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Selective culture of <i>Escherichia coli<\/i> to prevent infective complications of transrectal ultrasound\u2010guided prostate biopsy: Clinical efficacy and analysis of characteristics of quinolone\u2010resistant <i>Escherichia coli<\/i>"],"prefix":"10.1111","volume":"26","author":[{"given":"Yoshiki","family":"Hiyama","sequence":"first","affiliation":[{"name":"Department of Urology Sapporo Medical University School of Medicine Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Infection Control and Laboratory Medicine Sapporo Medical University School of Medicine Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruhisa","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urology Hokkaido Medical Center for Child Health and Rehabilitation Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Ichihara","sequence":"additional","affiliation":[{"name":"Department of Urology Sapporo Central Hospital Sapporo Hokkaido 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