{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T16:05:52Z","timestamp":1792944352561,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the correlation among bladder inflammation, angiogenesis, fibrosis and urothelial denudation in biopsied bladder specimens, and O'Leary\u2010Sant symptom indexes, O'Leary\u2010Sant problem indexes and visual analog scale pain scores in interstitial cystitis\/bladder pain syndrome patients with or without Hunner lesions (Hunner type interstitial cystitis or non\u2010Hunner type interstitial cystitis).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Bladder biopsied tissues were collected from 12 Hunner type interstitial cystitis female patients, 12 non\u2010Hunner type interstitial cystitis female patients and 12 age\u2010matched non\u2010interstitial cystitis female patients (controls). Immunohistochemical stainings of tissue necrotic factor\u2010\u03b1, mast cell tryptase, vascular endothelial growth factor, CD31, transforming growth factor\u2010\u03b2, SLUG associated with epithelial mesenchymal transition and E\u2010cadherin as well as Masson trichrome staining were evaluated. The significant correlation between the expression of tissue necrotic factor\u2010\u03b1, mast cell tryptase, vascular endothelial growth factor, CD31, transforming growth factor\u2010\u03b2, collagen, SLUG or E\u2010cadherin, and O'Leary\u2010Sant symptom indexes, O'Leary\u2010Sant problem indexes or visual analog scale pain scores was then examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The expression of tissue necrotic factor\u2010\u03b1, vascular endothelial growth factor, CD31, transforming growth factor\u2010\u03b2 and SLUG was significantly increased in non\u2010Hunner type interstitial cystitis and Hunner type interstitial cystitis patients compared with controls whereas the significant increases in the expression of mast cell tryptase and collagen were observed in Hunner type interstitial cystitis patients compared with controls and non\u2010Hunner type interstitial cystitis patients. On the other hand, the expression of E\u2010cadherin was significantly decreased in Hunner type interstitial cystitis patients compared with controls and non\u2010Hunner type interstitial cystitis patients. In addition, the increased expression of CD31 in bladder tissues was strongly correlated with O'Leary\u2010Sant symptom indexes, O'Leary\u2010Sant problem indexes and visual analog scale pain scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that bladder angiogenesis evident as the increased expression of CD31 is strongly correlated with urinary frequency and bladder pain in patients with non\u2010Hunner type interstitial cystitis and Hunner type interstitial cystitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.13972","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T09:22:36Z","timestamp":1559208156000},"page":"35-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Angiogenesis in bladder tissues is strongly correlated with urinary frequency and bladder pain in patients with interstitial cystitis\/bladder pain syndrome"],"prefix":"10.1111","volume":"26","author":[{"given":"Akira","family":"Furuta","sequence":"first","affiliation":[{"name":"Department of Urology Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Metropolitan Rehabilitation Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Department of Urology Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Urology Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Urology 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