{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:21:53Z","timestamp":1778030513800,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T00:00:00Z","timestamp":1557619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the effectiveness of intravesical irrigation with physiological saline solution or distilled water for the prevention of bladder recurrence in patients undergoing laparoscopic nephroureterectomy for upper urinary tract urothelial carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study involved 109 upper urinary tract urothelial carcinoma patients who underwent laparoscopic nephroureterectomy, and were evaluated at Chiba University Hospital and Yokohama Rosai Hospital between 2001 and 2018. We investigated the outcomes and analyzed various clinical factors including with or without intravesical irrigation related to bladder carcinoma recurrence after surgery. Physiological saline solution or distilled water was used for irrigation, which was carried out only during surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up period after surgery was 26.1\u00a0months. Bladder recurrence was confirmed within 2\u00a0years for 45 of the 109 patients in the present study. Irrigation was carried out for 48 cases (distilled water, 26 patients; physiological saline solution, 22 patients). Tumor grade (G1\u20132 <jats:italic>vs<\/jats:italic> G3; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05) and intravesical irrigation (yes <jats:italic>vs<\/jats:italic> no; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0058) were related to bladder recurrence on univariate analyses. On multivariate analyses, intravesical irrigation was the independent factor involved in the prevention of bladder recurrence (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0051). Comparison between the irrigation and non\u2010irrigation groups showed that bladder recurrence rates were significantly lower in the irrigation group (irrigation group <jats:italic>vs<\/jats:italic> non\u2010irrigation group: 25.0% <jats:italic>vs<\/jats:italic> 52.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0066). There was no significant difference in the recurrence rate between the two solutions used for irrigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravesical irrigation during surgery of upper urinary tract urothelial carcinoma might decrease postoperative bladder recurrence rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14014","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T05:25:56Z","timestamp":1557725156000},"page":"791-796","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Intravesical irrigation might prevent bladder recurrence in patients undergoing radical nephroureterectomy for upper urinary tract urothelial carcinoma"],"prefix":"10.1111","volume":"26","author":[{"given":"Satoshi","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Urology Chiba University Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Chiba University Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Urology Chiba University Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomokazu","family":"Sazuka","sequence":"additional","affiliation":[{"name":"Department of Urology Chiba University Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Urology Chiba University Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihito","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Urology Yokohama Rosai Hospital Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuto","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Urology Yokohama Rosai Hospital Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanetaka","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Urology Yokohama Rosai Hospital Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Urology Yokohama Rosai Hospital Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Urology Yokohama Rosai Hospital Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Urology Chiba University Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2009.06.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92066-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(06)00256-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13054"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10544"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199203123261108"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.2128"},{"key":"e_1_2_8_9_1","first-page":"213","article-title":"Effect of prophylactic intravesical instillation of pirarubicin to prevent recurrent bladder tumors following nephroureterectomy for upper urinary tract cancer","volume":"59","author":"Nagashima M","year":"2013","journal-title":"Hinyokika. 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