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Over the past three decades, hyperbaric oxygen has been used in a variety of conditions, including radiation\u2010induced tissue injuries, non\u2010healing states with ischemia and malignant neoplasms. In the field of urology, hyperbaric oxygen has also been applied to some pathological conditions (e.g. radiation\u2010induced hemorrhagic cystitis, Fournier gangrene, interstitial cystitis, male infertility, acute kidney injury and urological cancers). In normal and injured tissues, hyperoxia from hyperbaric oxygen therapy contributes to anti\u2010inflammation, angiogenesis through endothelial proliferation, enhanced fibroblastic activity, increased lymphocyte and macrophage activity, and bactericidal effects with the aim of wound repair. In cancerous tissues, the enhanced supply of oxygen into the hypoxic cancer cells can exert inhibitory effects on factors that contribute to their aggressiveness (e.g. cell survival, escape from apoptosis, epithelial\u2010to\u2010mesenchymal transition and tumor immunotolerance), and sensitize the tumor to radiation therapy and chemotherapy. However, further research, including multicenter clinical studies, is essential for determining the role of hyperbaric oxygen therapy in refractory urological diseases that are resistant to conventional therapies.<\/jats:p>","DOI":"10.1111\/iju.14015","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T23:49:06Z","timestamp":1557791346000},"page":"860-867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Potential of hyperbaric oxygen in urological diseases"],"prefix":"10.1111","volume":"26","author":[{"given":"Tomoaki","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Urology Suita Municipal Hospital Suita Osaka Japan"},{"name":"Department of Urology Osaka City University Graduate School of Medicine Osaka Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka City University Graduate School of Medicine Osaka Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka City University Graduate School of Medicine Osaka Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Nakatani","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka City University Graduate School of Medicine Osaka Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-196409000-00009"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2006.78"},{"key":"e_1_2_13_4_1","first-page":"93","article-title":"Histologic morphometry confirms a prophylactic effect for hyperbaric oxygen in the prevention of delayed radiation enteropathy","volume":"25","author":"Feldmeier JJ","year":"1998","journal-title":"Undersea Hyperb. 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