{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:21Z","timestamp":1787014341762,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T00:00:00Z","timestamp":1561852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K18573"],"award-info":[{"award-number":["JP19K18573"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To study the promotive effect of salt\u2010induced hypertension on crystal deposition and urolithiasis using a salt\u2010sensitive rat hypertension model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Hyperoxaluria and hypercalciuria were induced in male Dahl salt\u2010sensitive rats with administration of ethylene glycol and alfacalcidol. Hypertension was induced by a high\u2010salt diet. Eplerenone, a selective mineralocorticoid receptor antagonist, was given. Blood and urine were collected to evaluate renal function, electrolytes and the blood renin\u2013angiotensin\u2013aldosterone system. Renal calcium content was also evaluated. Histological examination, transcriptome analysis with\n                      <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                      microarray and semiquantitative reverse transcriptase polymerase chain reaction were carried out.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A high\u2010salt diet increased crystal deposition in Dahl salt\u2010sensitive rats with hypertension, and eplerenone administration significantly suppressed it. The\n                      <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                      expression profile was associated with crystal formation, growth, adhesion and cellular injury, and it was regulated in the group exposed to a high\u2010salt diet and ethylene glycol.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A high\u2010salt diet has a promotive effect on salt\u2010sensitive hypertension and urolithiasis. This promotive effect can be prevented by eplerenone administration. Hence, salt\u2010sensitive hypertension has promotive effects on crystal deposition in Dahl salt\u2010sensitive rats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.14035","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T01:39:51Z","timestamp":1561945191000},"page":"839-846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["High\u2010salt diet promotes crystal deposition through hypertension in Dahl salt\u2010sensitive rat model"],"prefix":"10.1111","volume":"26","author":[{"given":"Yusuke","family":"Nakazawa","sequence":"first","affiliation":[{"name":"Department of Urology Kanazawa Medical University Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Urology Kanazawa Medical University Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Medical Research Institute Kanazawa Medical University Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of General Education Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Ishigaki","sequence":"additional","affiliation":[{"name":"Medical Research Institute Kanazawa Medical University Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhito","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Department of Urology Kanazawa Medical University Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13552"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.09.034"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2006.tb00214.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00483.x"},{"key":"e_1_2_8_6_1","first-page":"319828","article-title":"Intersalt: an international study of electrolyte excretion and blood pressure. 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