{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T23:53:32Z","timestamp":1746489212003},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the efficacy, safety and cost of combinations of perineal pudendal nerve block\u00a0+\u00a0periprostatic nerve block and intrarectal local anesthesia\u00a0+\u00a0periprostatic nerve block with the standard technique (periprostatic nerve block).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was designed as a randomized prospective controlled trial. Patients with elevated serum prostate\u2010specific antigen values (prostate\u2010specific antigen\u00a0\u22654\u00a0ng\/mL) and\/or abnormal digital rectal examination findings were included in the study. Patients with anorectal diseases, chronic prostatitis, previous history of prostate biopsy and anorectal surgery were excluded from the study. A total of 148 patients (group\u00a01 [periprostatic nerve block], <jats:italic>n<\/jats:italic> = 48; group\u00a02 [intrarectal local anesthesia\u00a0+\u00a0periprostatic nerve block], <jats:italic>n<\/jats:italic> = 51; group\u00a03 [perineal pudendal nerve block\u00a0+\u00a0periprostatic nerve block], <jats:italic>n<\/jats:italic> = 49) were included in the final analysis. Pain during insertion and manipulation of the transrectal ultrasound probe was recorded as visual analog scale\u00a01, pain during penetration of the biopsy needle into the prostate and sampling was recorded as visual analog scale\u00a02, and pain during the entire procedure recorded as visual analog scale\u00a03.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean visual analog scale\u00a01 score was significantly lower in group\u00a03, when compared with group\u00a01 and group\u00a02 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). There was no significant difference between the groups in terms of the mean visual analog scale\u00a02 score. The mean visual analog scale\u00a03 score was significantly lower in group\u00a03 when compared with other groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The total cost for transrectal ultrasound\u2010guided biopsy in the intrarectal local anesthesia\u00a0+\u00a0periprostatic nerve block group was significantly higher than the other two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of perineal pudendal nerve block and periprostatic nerve block provides more effective pain control than intrarectal local anesthesia plus periprostatic nerve block and periprostatic nerve block alone, with similar complication rates and without increasing cost.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14036","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T01:14:47Z","timestamp":1560820487000},"page":"833-838","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Periprostatic nerve block alone versus combined with perineal pudendal nerve block or intrarectal local anesthesia during transrectal ultrasound\u2010guided prostate biopsy: A prospective randomized controlled trial"],"prefix":"10.1111","volume":"26","author":[{"given":"Rahmi","family":"Aslan","sequence":"first","affiliation":[{"name":"Department of Urology Yuzuncu Yil University Medical Faculty Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akif","family":"Erbin","sequence":"additional","affiliation":[{"name":"Department of Urology Haseki Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebahattin","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of General Surgery Yuzuncu Yil University Medical Faculty Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burak","family":"Ucpinar","sequence":"additional","affiliation":[{"name":"Department of Urology Haseki Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Recep","family":"Eryilmaz","sequence":"additional","affiliation":[{"name":"Department of Urology Yuzuncu Yil University Medical Faculty Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerem","family":"Taken","sequence":"additional","affiliation":[{"name":"Department of Urology Yuzuncu Yil University Medical Faculty Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.08.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01538-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.04.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2012.53.8.547"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16392-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.06990.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.10.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12542"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-1433.2003.02885.x"},{"key":"e_1_2_8_11_1","first-page":"1862","article-title":"Local perianal nerve block versus spinal block for closed hemorrhoidectomy: a randomized controlled trial","volume":"91","author":"Anannamcharoen S","year":"2008","journal-title":"J. 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