{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:13:07Z","timestamp":1762607587694},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T00:00:00Z","timestamp":1563667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the 10\u2010year biopsy\u2010proven recurrence rates and risk factors for immunoglobulin\u00a0A nephropathy recurrence in kidney transplant recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 299 kidney transplant recipients from 1995 to 2015, who had biopsy\u2010proven underlying immunoglobulin\u00a0A nephropathy and underwent zero\u2010hour biopsy. The primary end\u2010point was recurrence of immunoglobulin\u00a0A nephropathy. We compared clinical, treatment and graft failure among those with and without recurrent immunoglobulin\u00a0A nephropathy. A time\u2010to\u2010recurrence analysis was carried out using the competing risk analysis and time\u2010dependent Cox model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 299 recipients, 80 had recurrent immunoglobulin\u00a0A nephropathy (66.3% with clinical biopsy and 33.7% with protocol biopsy, post\u2010transplant biopsy rate: 90.6%). The 10\u2010year recurrence rate was 34.3% (95% confidence interval 27.6\u201341.1). Related\u2010donor transplantation (hazard ratio 2.28, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009) and post\u2010transplant increased proteinuria (hazard ratio 1.59, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) were identified as potential risk factors for immunoglobulin\u00a0A nephropathy recurrence. The 10\u2010year rates were 41.5% in related donor recipients and 16.3% in unrelated donor recipients. There was no conclusive evidence that the calcineurin inhibitor, antimetabolites, basiliximab and rituximab reduce immunoglobulin\u00a0A nephropathy recurrence. Immunoglobulin\u00a0A nephropathy recurrence was associated with an increased risk of death\u2010censored graft failure (hazard ratio 5.29, 95% confidence interval 1.39\u201320.17, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.015). However, related donor itself was not associated with an increased risk of graft failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present results have clinical implications in that the signs of recurrent immunoglobulin\u00a0A nephropathy should be evaluated carefully in recipients receiving related\u2010donor transplants. There is a need for further studies related to genetic and\/or familial interactions in kidney transplant recipients with immunoglobulin\u00a0A nephropathy and related donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14066","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T05:24:08Z","timestamp":1563773048000},"page":"903-909","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Higher immunoglobulin\u00a0A nephropathy recurrence in related\u2010donor kidney transplants: The Japan Academic Consortium of Kidney Transplantation study"],"prefix":"10.1111","volume":"26","author":[{"given":"Masayoshi","family":"Okumi","sequence":"first","affiliation":[{"name":"Departments of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daigo","family":"Okada","sequence":"additional","affiliation":[{"name":"Departments of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Unagami","sequence":"additional","affiliation":[{"name":"Organ Transplant Medicine Tokyo Women\u2019s Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Kakuta","sequence":"additional","affiliation":[{"name":"Departments of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junpei","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Departments of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Takagi","sequence":"additional","affiliation":[{"name":"Departments of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Shirakawa","sequence":"additional","affiliation":[{"name":"Department of Urology Ohkubo Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Omoto","sequence":"additional","affiliation":[{"name":"Department of Urology Toda Chuo General Hospital Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Organ Transplant Medicine Tokyo Women\u2019s Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Departments of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Japan Academic Consortium of Kidney Transplantation (JACK)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg102"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00801-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr664"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001093"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2017.01.005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2004.01.008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-013-0779-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13135"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13502"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft355"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.328"},{"key":"e_1_2_8_14_1","first-page":"309","article-title":"Recurrent mesangial IgA nephritis following renal transplantation","volume":"9","author":"Odum J","year":"1994","journal-title":"Nephrol. 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