{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:37:10Z","timestamp":1793223430995,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010740","name":"Asahi Kasei Pharma Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010740","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To elucidate the mechanism of action of the \u03b1<jats:sub>1<\/jats:sub>\u2010blocker, naftopidil, in partial bladder outlet obstruction animals, by studying non\u2010voiding contractions, and the levels of mediators were measured with resiniferatoxin treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 35 female Wistar rats were randomly divided into a sham or bladder outlet obstruction group, and rats in each group were given vehicle or resiniferatoxin. Incomplete urethral ligation was applied to the bladder outlet obstruction group. After cystometry, the intravesical level of prostaglandin\u00a0E<jats:sub>2<\/jats:sub> and adenosine 5\u2032\u2010triphosphate was measured in the instilled perfusate collected. Naftopidil was given at the time of cystometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In bladder outlet obstruction rats, non\u2010voiding contractions, bladder capacity, and the intravesical levels of prostaglandin\u00a0E<jats:sub>2<\/jats:sub> and adenosine 5\u2032\u2010triphosphate were markedly increased compared with sham rats. Naftopidil decreased non\u2010voiding contractions, enlarged the bladder capacity, and decreased the intravesical levels of prostaglandin\u00a0E<jats:sub>2<\/jats:sub> and adenosine 5\u2032\u2010triphosphate. Resiniferatoxin enhanced non\u2010voiding contractions. The effects of naftopidil on non\u2010voiding contractions and the intravesical level of prostaglandin E<jats:sub>2<\/jats:sub>, but not adenosine 5\u2032\u2010triphosphate, were tolerant to resiniferatoxin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In bladder outlet obstruction rats, one cause of generation of non\u2010voiding contractions might be bladder wall distension, but not transient receptor potential cation channel\u00a0V1. The increase in intravesical prostaglandin\u00a0E<jats:sub>2<\/jats:sub> might also be associated with the generation of non\u2010voiding contractions. Naftopidil inhibits the increase in non\u2010voiding contractions and decreases the intravesical level of prostaglandin\u00a0E<jats:sub>2<\/jats:sub>, which are independent of transient receptor potential cation channel\u00a0V1.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14069","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T01:04:38Z","timestamp":1563411878000},"page":"924-930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["\u03b1<sub>1<\/sub>\u2010Blocker inhibits non\u2010voiding contractions and decreases the level of intravesical prostaglandin\u00a0E<sub>2<\/sub> in rats with partial bladder outlet obstruction"],"prefix":"10.1111","volume":"26","author":[{"given":"Hironobu","family":"Akino","sequence":"first","affiliation":[{"name":"Department of Urology Faculty of Medical Sciences University of Fukui Fukui 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