{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:01:25Z","timestamp":1776052885437,"version":"3.50.1"},"reference-count":108,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A worldwide increase in antimicrobial\u2010resistant microbes due to the improper use of antimicrobial agents, along with a lack of progress in developing new antimicrobials, is becoming a societal problem. Although carbapenem\u2010resistant Enterobacteriaceae, which are resistant to carbapenem antimicrobials, first appeared in 1993, treatment options remain limited. Mechanisms behind antimicrobial resistance involve changes to microbial outer membranes, drug efflux pump abnormalities, \u03b2\u2010lactamase production and the creation of biofilms around cell bodies. Genetic information related to these forms of antimicrobial resistance exists on chromosomes and plasmids, and when located on the latter can easily be transmitted to other strains, no matter the species, which creates a risk of antimicrobial resistance spreading exceptionally rapidly. To prevent the spread of antimicrobial resistance, the World Health Organization in 2015 published an action plan on antimicrobial resistance, based on which World Health Organization member countries have laid out specific policies and targets. Urinary tract infections are a type of healthcare\u2010associated infection, and the sexually transmitted disease pathogen, <jats:italic>Neisseria gonorrhoeae<\/jats:italic>, has been included in a list of microbes that pose a risk to human health published by the US Centers for Disease Control and Prevention. Urologists face numerous problems when attempting to use antimicrobials properly, which is one method of dealing with antimicrobial resistance. Therefore, this article describes the current state of resistant microbes associated with urinary tract infections and countermeasures for antimicrobial resistance, including new antimicrobials.<\/jats:p>","DOI":"10.1111\/iju.14087","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T23:33:46Z","timestamp":1565048026000},"page":"1090-1098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Current status of countermeasures for infectious diseases and resistant microbes in the field of urology"],"prefix":"10.1111","volume":"26","author":[{"given":"Hiroyuki","family":"Kitano","sequence":"first","affiliation":[{"name":"Department of Urology Hiroshima University Hiroshima City Hiroshima Japan"},{"name":"Department of Infectious Diseases Hiroshima University Hospital Hiroshima City Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Teishima","sequence":"additional","affiliation":[{"name":"Department of Urology Hiroshima University Hiroshima City Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Shigemura","sequence":"additional","affiliation":[{"name":"Department of Urology Kobe University Kobe City Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Ohge","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hiroshima University Hospital Hiroshima City Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Urology Kobe University Kobe City Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Urology Hiroshima University Hiroshima City Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.174"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00540-16"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2017.03.010"},{"key":"e_1_2_9_5_1","unstructured":"Centers for Disease Control and Prevention.Antibiotic resistance threats in the United States 2013. [Cited 22 Feb 2019.] Available from URL:https:\/\/www.cdc.gov\/drugresistance\/threat-report-2013\/pdf\/ar-threats-2013-508.pdf"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2014.8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13873"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt477"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt129"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg254"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00001-07"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.050708-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70143-2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70190-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acuro.2017.08.004"},{"key":"e_1_2_9_16_1","first-page":"450","article-title":"Useful independent factors for distinguish infection and colonization in patients with urinary carbapenemase\u2010producing Enterobacteriaceae isolation","volume":"30","author":"Lopez\u2010Gonzalez L","year":"2017","journal-title":"Rev. Esp. Quimioter."},{"key":"e_1_2_9_17_1","unstructured":"O'NeillJ.Antimicrobial resistance: tackling a crisis for the health and wealth of nations. The review on antimicrobial resitance London 2014."},{"key":"e_1_2_9_18_1","unstructured":"Centers for Disease Control and Prevention.III. Precautions to prevent transmission of infectious agents. [Cited 27 Jul 2019.] Available from URL:https:\/\/www.cdc.gov\/infectioncontrol\/guidelines\/isolation\/precautions.html"},{"key":"e_1_2_9_19_1","unstructured":"Centers for Disease Control and Prevention.Biggest threats and data. [Cited 22 Feb 2019.] Available from URL:https:\/\/www.cdc.gov\/drugresistance\/biggest_threats.html"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(03)00193-3"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e318286bb53"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00596a010"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-114-2-305"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1128\/jb.145.2.736-742.1981","article-title":"Structural comparison of Neisseria gonorrhoeae outer membrane proteins","volume":"145","author":"Heckels JE","year":"1981","journal-title":"J. Bacteriol."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.157.5.1405"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.137.3.571"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90366-1"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.12.3744-3749.2002"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656560902731993"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2010.045377"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.1.137-143.2005"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-011-0169-9"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp505"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2010.042648"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01604-06"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/332173a0"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1701.100397"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00325-11"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05760-11"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks162"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1408109"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01295-13"},{"key":"e_1_2_9_43_1","unstructured":"Centers for Disease Control and Prevention.Sexually Transmitted Disease Surveillance 2016: Gonococcal Isolate Surveillance Project (GISP). [Cited 22 Feb 2019.] Available from URL:https:\/\/www.cdc.gov\/std\/stats16\/gisp2016\/docs\/gisp_2016_supplement_final_2018.pdf"},{"key":"e_1_2_9_44_1","unstructured":"Centers for Disease Control and Prevention.2015 Sexually transmitted disease treatment guidelines. [Cited 22 Feb 2019.] Available from URL:https:\/\/www.cdc.gov\/std\/tg2015\/gonorrhea.htm"},{"key":"e_1_2_9_45_1","unstructured":"European Association of Urology.Urological infection. [Cited 22 Feb 2019.] Available from URL:https:\/\/uroweb.org\/guideline\/urological-infections\/#3_10"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706988"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix450"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00006-11"},{"key":"e_1_2_9_49_1","first-page":"524","article-title":"Urogenital mycoplasma infections of man: a review with observations on a recently discovered mycoplasma","volume":"17","author":"Taylor\u2010Robinson D","year":"1981","journal-title":"Isr. J. Med. Sci."},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/139.4.478"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92461-2"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-33-2-387"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.34.2.286-291.1996"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2006.022970"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1086\/656739"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2005.074062"},{"key":"e_1_2_9_57_1","first-page":"119","article-title":"The biology of Mycoplasma genitalium","volume":"2000","author":"Taylor\u2010Robinson D","year":"2000","journal-title":"Venereology"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003618"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.79.4.318"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1086\/599034"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035593"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462413502008"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156740"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02312-16"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13849"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu1162"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0781-7"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-012-0392-9"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-013-0620-y"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04945-14"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02411-14"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00358-13"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw405"},{"key":"e_1_2_9_74_1","unstructured":"Center for Disease Dynamics Economics & Policy.State of the world's antibiotics 2015.2015. [Cited 17 May 2017.] Available from URL:http:\/\/cddep.org\/sites\/default\/files\/swa_2015_final.pdf"},{"key":"e_1_2_9_75_1","volume-title":"Antimicrobial resistance: global report on surveillance 2014","author":"World Health Organization"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1868"},{"key":"e_1_2_9_77_1","unstructured":"The Pew Charitable Trusts.Antibiotics currently in clinical development 2019. [Cited 11 Mar 2019.] Available from URL:https:\/\/www.pewtrusts.org\/en\/research-and-analysis\/data-visualizations\/2014\/antibiotics-currently-in-clinical-development"},{"key":"e_1_2_9_78_1","unstructured":"The Pew Charitable Trusts.Antibiotics currently in clinical development 2019. [Cited 11 Mar 2019.] Available from URL:https:\/\/www.pewtrusts.org\/-\/media\/assets\/2019\/03\/antibiotics-currently-in-global-clinical-development.pdf?la=en&hash=078238EF15FACD9753ED2C4EBAB58F16B664B59E"},{"key":"e_1_2_9_79_1","unstructured":"The White House.National action plan for combating antibioticresistant bacteria.2015. [Cited 11 Mar 2019.] Available from URL:https:\/\/obamawhitehouse.archives.gov\/sites\/default\/files\/docs\/national_action_plan_for_combating_antibotic-resistant_bacteria.pdf"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv339"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30753-3"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.12480"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw741"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw090"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01275-10"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13205"},{"key":"e_1_2_9_87_1","unstructured":"BonkatG BartolettiRR Bruy\u00e8reFet al.Urological infections. [Cited 15 Mar 2019.] Available from URL:https:\/\/uroweb.org\/guideline\/urological-infections\/#3"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00756-10"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03057-14"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00414-18"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00472-17"},{"key":"e_1_2_9_92_1","unstructured":"ClinicalTrials.gov.Identifier:NCT02655419. [Cited 16 Mar 2019.] Available from URL:https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02655419"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01405-16"},{"key":"e_1_2_9_94_1","first-page":"45","article-title":"Trojan horse antibiotics \u2013 a novel way to circumvent Gram\u2010negative bacterial resistance?","volume":"9","author":"Tillotson GS","year":"2016","journal-title":"Infect. Dis."},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03098-15"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30554-1"},{"key":"e_1_2_9_97_1","unstructured":"ClinicalTrials.gov.Identifier:NCT 02714595. [Cited 17 Mar 2019.] Available from URL:https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02714595"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-015-2375-0"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0851-9"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00830-15"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05927-11"},{"key":"e_1_2_9_102_1","first-page":"2286","article-title":"Activity of MK\u20107655 combined with imipenem against Enterobacteriaceae and Pseudomonas aeruginosa","volume":"68","author":"Livermore DM","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx139"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00843-15"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01443-17"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00711-16"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01694-17"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.0438"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piz002"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiju.14087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.14087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iju.14087","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.14087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T10:51:32Z","timestamp":1694256692000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.14087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,5]]},"references-count":108,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/iju.14087"],"URL":"https:\/\/doi.org\/10.1111\/iju.14087","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,5]]},"assertion":[{"value":"2019-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}