{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:21:10Z","timestamp":1792639270945,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T00:00:00Z","timestamp":1569024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antidepressant medications are commonly used in males of reproductive age for long\u2010term treatment of depression, as well as other disorders. Although antidepressants are known to be associated with sexual side\u2010effects, their effects on semen parameters and other markers of male fertility have been less thoroughly described. The majority of available studies have focused on selective serotonin reuptake inhibitors, which have been shown to negatively impact semen quality in <jats:italic>in\u00a0vitro<\/jats:italic>, animal and human studies. Fluoxetine, in particular, has been the subject of multiple studies and has been associated with gonadotoxic effects, including decreased sperm concentration and motility, increased deoxyribonucleic acid fragmentation, and decreased reproductive organ weights. Studies of several other selective serotonin reuptake inhibitors have yielded similar results. Reassuringly, this effect does seem to be reversible. The data regarding serotonin\u2013norepinephrine reuptake inhibitors, norepinephrine\u2013dopamine reuptake inhibitors, tricyclic antidepressants, monoamine oxidase inhibitors and atypical antidepressants are sparse, varied and conflicting. Given the widespread and often long\u2010term use of antidepressant medications, there is a clear need for further data regarding their impact on semen quality and male fertility.<\/jats:p>","DOI":"10.1111\/iju.14111","type":"journal-article","created":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T01:43:35Z","timestamp":1569116615000},"page":"39-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Effect of antidepressant medications on semen parameters and male fertility"],"prefix":"10.1111","volume":"27","author":[{"given":"Lauren A","family":"Beeder","sequence":"first","affiliation":[{"name":"Keck School of Medicine University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K","family":"Samplaski","sequence":"additional","affiliation":[{"name":"Institute of Urology University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,21]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Antidepressant Use among Persons Aged 12 and over: United States, 2011\u20132014","author":"Pratt LA","year":"2017"},{"key":"e_1_2_10_3_1","volume-title":"OECD Health Statistics","author":"Organisation for Economic Co-operation and Development","year":"2015"},{"key":"e_1_2_10_4_1","first-page":"32","article-title":"Antidepressant drug development in Japan: current & future horizons","volume":"16","author":"Berger D","year":"2005","journal-title":"Clin. 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